ArticleMolecular brain2014
No requirement of TRPV1 in long-term potentiation or long-term depression in the anterior cingulate cortex.
Article in Molecular brain, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 19 citations in OpenAlex.
- Dry Eye Disease and Psychiatric Disorders: Neuroimmune Mechanisms and Therapeutic Perspectives.International journal of molecular sciences · 2025Review
- Cortical Potentiation in Chronic Neuropathic Pain and the Future Treatment.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Sex difference in synaptic plasticity in the anterior cingulate cortex of adult mice.Molecular brain · 2020Article
- Protein Kinase C Lambda Mediates Acid-Sensing Ion Channel 1a-Dependent Cortical Synaptic Plasticity and Pain Hypersensitivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Loss of Synaptic Tagging in the Anterior Cingulate Cortex after Tail Amputation in Adult Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Nociceptive TRP Channels: Sensory Detectors and Transducers in Multiple Pain Pathologies.Pharmaceuticals (Basel, Switzerland) · 2016Review
- Synaptic plasticity in the anterior cingulate cortex in acute and chronic pain.Nature reviews. Neuroscience · 2016Review
- Acid-sensing ion channel 1a contributes to hippocampal LTP inducibility through multiple mechanisms.Scientific reports · 2016Article
- Glucagon-Like Peptide-1 Excites Firing and Increases GABAergic Miniature Postsynaptic Currents (mPSCs) in Gonadotropin-Releasing Hormone (GnRH) Neurons of the Male Mice via Activation of Nitric Oxide (NO) and Suppression of Endocannabinoid Signaling Pathways.Frontiers in cellular neuroscience · 2016Article
- Metabotropic Glutamate Receptor Dependent Cortical Plasticity in Chronic Pain.Current neuropharmacology · 2016Review
- Theta-burst LTP.Brain research · 2015Review
- Pain perception in acute model mice of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).Molecular pain · 2015Article
- Minocycline does not affect long-term potentiation in the anterior cingulate cortex of normal adult mice.Molecular pain · 2015Article
- Impaired presynaptic long-term potentiation in the anterior cingulate cortex of Fmr1 knock-out mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Sensory TRP channels: the key transducers of nociception and pain.Progress in molecular biology and translational science · 2015Review
- No requirement of interlukine-1 for long-term potentiation in the anterior cingulate cortex of adult mice.Molecular painArticle
- Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One major interest in the study of transient receptor potential vanilloid type 1 (TRPV1) in sensory system is that it may serve as a drug target for treating chronic pain. While the roles of TRPV1 in peripheral nociception and sensitization have been well documented, less is known about its contribution to pain-related cortical plasticity. Here, we used 64 multi-electrode array recording to examine the potential role of TRPV1 in two major forms of synaptic plasticity, long-term potentiation (LTP) and long-term depression (LTD), in the anterior cingulate cortex (ACC). We found that pharmacological blockade of TRPV1 with either [(E)-3-(4-t-Butylphenyl)-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acrylamide] (AMG9810, 10 μM) or N-(3-methoxyphenyl)-4-chlorocinnamide (SB366791, 20 μM) failed to affect LTP induced by strong theta burst stimulation in the ACC of adult mice. Similarly, neither AMG9810 nor SB366791 blocked the cingulate LTD induced by low-frequency stimulation. Analysis of the results from different layers of the ACC obtained the same conclusions. Spatial distribution of LTP or LTD-showing channels among the ACC network was also unaltered by the TRPV1 antagonists. Since cortical LTP and LTD in the ACC play critical roles in chronic pain triggered by inflammation or nerve injury, our findings suggest that TRPV1 may not be a viable target for treating chronic pain, especially at the cortical level.
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