ArticleBMC veterinary research2014
The effect of colostrum intake on blood plasma proteome profile in newborn lambs: low abundance proteins.
Article in BMC veterinary research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Overall Evidence for Milk-Derived Proteins and Peptides in Blood after Digestion: A Systematic Review.Nutrition reviews · 2025Pooled it
- Effect of Colostrum Components on Early Inflammatory Response, IgG Concentration and Weight Gain in Lambs.Animals : an open access journal from MDPI · 2026Article
- Comparative Proteomic Analysis of Extracellular Vesicles from Donkey Colostrum and Mature Milk.Metabolites · 2025Article
- Article
- Maternal Supplementation with Dietary Betaine during Late Gestation Increased Ewe Plasma Creatine and Lamb Thermoregulation under Field Conditions.Animals : an open access journal from MDPI · 2024Article
- Extensive Sheep and Goat Production: The Role of Novel Technologies towards Sustainability and Animal Welfare.Animals : an open access journal from MDPI · 2022Review
- Supplementing lycopene combined with corn improves circulating IgG concentration in pregnant ewes and their lambs.Tropical animal health and production · 2021Article
- The Differential Composition of Whey Proteomes in Hu Sheep Colostrum and Milk during Different Lactation Periods.Animals : an open access journal from MDPI · 2020Article
- Milk Replacer Supplementation with Docosahexaenoic Acid from Microalgae Does Not Affect Growth and Immune Status in Goat Kids.Animals : an open access journal from MDPI · 2020Article
- Use of Proteomics in the Study of Mastitis in Ewes.Pathogens (Basel, Switzerland) · 2019Review
- Changes of clinical, electrolytes, acute phase proteins, and some cardiovascular biomarkers in lambs and kids from birth to 2 days of age.Tropical animal health and production · 2019Article
- Selected reaction monitoring mass spectrometry of mastitis milk reveals pathogen-specific regulation of bovine host response proteins.Journal of dairy science · 2018Article
- The Effect of Weight Loss on the Muscle Proteome in the Damara, Dorper and Australian Merino Ovine Breeds.PloS one · 2016Article
- Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundColostrum intake by newborn lambs plays a fundamental role in the perinatal period, ensuring lamb survival. In this study, blood plasma samples from two groups of newborn lambs (Colostrum group and Delayed Colostrum group) at 2 and 14 h after birth were treated to reduce the content of high abundance proteins and analyzed using Two-Dimensional Differential in Gel Electrophoresis and MALDI MS/MS for protein identification in order to investigate low abundance proteins with immune function in newborn lambs.
resultsThe results showed that four proteins were increased in the blood plasma of lambs due to colostrum intake. These proteins have not been previously described as increased in blood plasma of newborn ruminants by colostrum intake. Moreover, these proteins have been described as having an immune function in other species, some of which were previously identified in colostrum and milk.
conclusionsIn conclusion, colostrum intake modified the low abundance proteome profile of blood plasma from newborn lambs, increasing the concentration of apolipoprotein A-IV, plasminogen, serum amyloid A and fibrinogen, demonstrating that colostrum is essential, not only for the provision of immunoglobulins, but also because of increases in several low abundance proteins with immune function.
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Registered trials
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