ArticleBMC cardiovascular disorders2014
Diagonal earlobe crease and coronary artery disease in a Chinese population.
Article in BMC cardiovascular disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07427745 (PRESENCE OF FRANK'S SIGN), which is not on this map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Presence of frank's sign: a comparative evaluation in smokers and non-smokers
Who cites it
16 citing papers in PubMed.
- Association of advanced glycation end products with ear lobe crease: A cross-sectional study.Journal of diabetes · 2024Article
- Traditional Cardiovascular Risk Factors Associated with Diagonal Earlobe Crease (Frank Sign) in Mexican Adults: Aging, Obesity, Arterial Hypertension, and Being Male Are the Most Important.International journal of hypertension · 2024Article
- Clinical Value of the Diagonal Earlobe Crease in Patients with Chest Pain for Diagnosing Coronary Heart Disease.International journal of general medicine · 2024Article
- Cutaneous signs of selected cardiovascular disorders: A narrative review.Open medicine (Warsaw, Poland) · 2024Review
- The prognostic value of the Frank sign.Forensic science, medicine, and pathology · 2022Article
- Diagonal Earlobe Crease (Frank's Sign) for Diagnosis of Coronary Artery Disease: A Systematic Review of Diagnostic Test Accuracy Studies.Journal of clinical medicine · 2021Review
- Adropin and Irisin Deficiencies Are Associated With Presence of Diagonal Earlobe Crease in CAD Patients.Frontiers in cardiovascular medicine · 2021Article
- Patients with Earlobe Crease May Associate with Lower Concentration of the Age-Suppressing Hormone Klotho.International journal of general medicine · 2021Article
- The Association between Earlobe Creases and Cardiovascular Events in Japanese Hemodialysis Patients: A Prospective Cohort Study.Internal medicine (Tokyo, Japan) · 2020Article
- Preauricular Vertical Creases.Internal medicine (Tokyo, Japan) · 2019Article
- Association of calcified carotid artery plaque in panoramic images and diagonal earlobe crease.Dento maxillo facial radiology · 2019Article
- Diagonal Earlobe Crease is a Visible Sign for Cerebral Small Vessel Disease and Amyloid-β.Scientific reports · 2017Article
- Relationship between diagonal earlobe creases and coronary artery disease as determined via angiography.BMJ open · 2016Article
- Did Dumbo suffer a heart attack? independent association between earlobe crease and cardiovascular disease.BMC cardiovascular disorders · 2016Article
- Ear lobe crease: a marker of coronary artery disease?Archives of medical science : AMS · 2015Article
- Diagonal ear lobe crease: A premonitory diagnostic sign of impeding ischemic heart disease.Journal of family medicine and primary careArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMany reports have claimed associations between diagonal earlobe crease (DELC) and coronary artery disease (CAD), but data in Chinese populations are limited.
methodsThis cohort study investigated 449 consecutive Chinese, 250 cases with CAD and 199 without CAD, who were certified by coronary artery angiography in our center. Characteristic differences and the relation of DELC to CAD were assessed by Chi-square and t tests. The multivariate regression was performed to adjust for confounders and ROCs mode were used to detect its predicting performance for CAD.
resultsThe prevalence of DELC was 46.2% in those without CAD and 75.2% in those with CAD (P < .001). Subjects with DELC had more stenostic vessels and higher prevalence of both any and significant coronary artery stenosis than those without DELC (P < .001). The sensitivity, specificity and positive and negative predictive values for DELC to diagnose CAD in the whole population were 0.752, 0.538, 0.671 and 0.633. The higher sensitivity and positive predictive values (ppv) were found in male, the lowest sensitivity and the highest ppv in the <45 years old group, and the lowest specificity and ppv in the >75 years old group. After adjusting for other variables including age, gender and traditional risk factors, DELC remained a positive predictor for CAD (OR, 3.408; 95% CI 2.235-5.196; P < 0.001), but not for hypertension, diabetes mellitus, hypercholesterolemia and hypertriglyceridemia. ROC analysis showed the area under the curve was 0.645 (95% CI 0.593-0.697, p < 0.001).
conclusionsThe study showed a significant association between DELC and CAD independent of established risk factors in Chinese.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.