SynthesisBMC pregnancy and childbirth2014
A comparison of the prevalence of prenatal alcohol exposure obtained via maternal self-reports versus meconium testing: a systematic literature review and meta-analysis.
Synthesis in BMC pregnancy and childbirth, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
71 citing papers in PubMed, 3 syntheses or guidelines pooled it, 151 citations in OpenAlex.
- Family Needs Checklist: Development of a Mobile Application for Parents with Children to Assess the Risk for Child Maltreatment.International journal of environmental research and public health · 2022Pooled it
- Effectiveness of psychological interventions to reduce alcohol consumption among pregnant and postpartum women: a systematic review.Archives of women's mental health · 2021Pooled it
- Neurodevelopmental profile of Fetal Alcohol Spectrum Disorder: A systematic review.BMC psychology · 2017Pooled it
- Review
- Predictive value of alcohol use questionnaires for adverse pregnancy outcomes: Evidence from a Finnish birth cohort.Acta obstetricia et gynecologica Scandinavica · 2026Article
- Anonymous Diaper-Based Meconium Collection for Ethyl Glucuronide Analysis: A Pilot Feasibility Study.Toxics · 2026Article
- Dysmorphological and Neuropsychological Phenotypes of Prenatally Alcohol-Exposed 6-Year-Old Children: A Prospective Longitudinal Birth Cohort Study.Alcohol, clinical & experimental research · 2026Article
- Alcohol Consumption During Pregnancy and State Implementation of Legal Nonmedical Cannabis Retail Sales in the U.S., 2011-2023.American journal of preventive medicine · 2026Article
- A prospective cohort study to assess if alcohol intake measured by routine pregnancy self-report predicts developmental concerns uncovered by routine health visitor screening of children at 30 months of age.Archives of public health = Archives belges de sante publique · 2025Article
- Does paternal alcohol consumption affect the severity of traits of fetal alcohol spectrum disorders?Alcohol, clinical & experimental research · 2025Article
- Prenatal and Perinatal Factors Associated with Infant Acute Lymphoblastic Leukaemia: A Scoping Review.Cancers · 2025Review
- Association of perinatal characteristics with biomarkers of stress and inflammation in young adults: An exploratory study.Comprehensive psychoneuroendocrinology · 2024Article
- Screening of substance use in pregnancy: A Danish cross-sectional study.Acta obstetricia et gynecologica Scandinavica · 2024Article
- Associations between maternal periconceptional alcohol consumption and risk of omphalocele among offspring, National Birth Defects Prevention Study, 1997-2011.Preventive medicine · 2024Article
- Effects of prenatal alcohol exposition on cognitive outcomes in childhood and youth: a longitudinal analysis based on meconium ethyl glucuronide.European archives of psychiatry and clinical neuroscience · 2024Article
- Validity of prenatal AUDIT screening for alcohol disorders - a Nationwide Swedish register study.Upsala journal of medical sciences · 2024Article
- Impaired vision in children prenatally exposed to methadone: an observational cohort study.Eye (London, England) · 2024Observational
- Fetal Alcohol Spectrum Disorders and Inadequacy of Care: Importance of Raising Awareness in Clinical Practice.Children (Basel, Switzerland) · 2023Review
- Rapid urine screening for ethyl glucuronide from pregnant women as a tool for detecting prenatal alcohol exposure.BMC pregnancy and childbirth · 2023Article
- Fetal alcohol spectrum disorders.Nature reviews. Disease primers · 2023Review
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMaternal self-reports, used for the detection of prenatal alcohol exposure (PAE), may lack validity, necessitating the use of an objective biomarker. The detection of fatty acid ethyl esters (products of non-oxidative ethanol metabolism) in meconium has been established as a novel biomarker of PAE. The purpose of the current study was to compare the prevalence of PAE as reported via maternal self-reports with the results of meconium testing, and to quantify the disparity between these two methods.
methodsA systematic literature search for studies reporting on the prevalence of PAE, using maternal self-reports in combination with meconium testing, was conducted using multiple electronic bibliographic databases. Pooled prevalence estimates and 95% confidence intervals (CI) were calculated based on eight studies, using the Mantel-Haenszel method, assuming a random effects model. A random effects meta-regression was performed to test for a difference.
resultsThe pooled prevalence of PAE as measured by meconium testing was 4.26 (95% CI: 1.34-13.57) times the pooled prevalence of PAE as measured by maternal self-reports. Large variations across the studies in regard to the difference between estimates obtained from maternal self-reports and those obtained from meconium testing were observed.
conclusionsIf maternal self-reports are the sole information source upon which health care professionals rely, a number of infants who were prenatally exposed to alcohol are not being recognized as such. However, further research is needed in order to validate existing biomarkers, as well as discover new biomarkers, for the detection of PAE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.