ArticleBMC complementary and alternative medicine2014
Effect of methanol extract of Dicranopteris linearis against carbon tetrachloride-induced acute liver injury in rats.
Article in BMC complementary and alternative medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 50 citations in OpenAlex.
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- Bioactive-Guided Phytochemical Investigations, In Vitro and In Silico Alpha-Glucosidase Inhibition of Two Vietnamese Medicinal PlantsPharmaceuticals (Basel, Switzerland) · 2023Article
- Hepatoprotective Potential of Malaysian Medicinal Plants: A Review on Phytochemicals, Oxidative Stress, and Antioxidant Mechanisms.Molecules (Basel, Switzerland) · 2022Review
- Polyphenolics and triterpenes presence in chloroform extract of Dicranopteris linearis leaves attenuated paracetamol-induced liver intoxication in rat.BMC complementary medicine and therapies · 2021Article
- Hepatoprotective and antioxidant activities ofPharmaceutical biology · 2020Article
- Carbonization and HScientific reports · 2020Article
- Methanol Extract ofBiomolecules · 2020Article
- Aqueous Partition of Methanolic Extract ofNutrients · 2019Article
- Methanol extract of Muntingia calabura leaves attenuates CClPharmaceutical biology · 2019Article
- Dicranopteris linearis extract inhibits the proliferation of human breast cancer cell line (MDA-MB-231) via induction of S-phase arrest and apoptosis.Pharmaceutical biology · 2018Article
- Sicyos angulatus ameliorates acute liver injury by inhibiting oxidative stress via upregulation of anti-oxidant enzymes.Redox report : communications in free radical research · 2018Article
- Nephroprotective Effect of Zingerone against CClOxidative medicine and cellular longevity · 2018Article
- Methanol extract of Dicranopteris linearis L. leaves impedes acetaminophen-induced liver intoxication partly by enhancing the endogenous antioxidant system.BMC complementary and alternative medicine · 2017Article
- Urinary and Serum Metabolomics Analyses Uncover That Total Glucosides of Paeony Protect Liver against Acute Injury Potentially via Reprogramming of Multiple Metabolic Pathways.Evidence-based complementary and alternative medicine : eCAM · 2017Article
- Phytochemicals from fern species: potential for medicine applications.Phytochemistry reviews : proceedings of the Phytochemical Society of Europe · 2017Article
- Antinociception of petroleum ether fraction derived from crude methanol extract of Melastoma malabathricum leaves and its possible mechanisms of action in animal models.BMC complementary and alternative medicine · 2016Article
- Hepatoprotective effects of Micromeria croatica ethanolic extract against CCl4-induced liver injury in mice.BMC complementary and alternative medicine · 2015Article
- Hepato-protective effect of rutin via IL-6/STAT3 pathway in CCl4-induced hepatotoxicity in rats.Biological research · 2015Article
- Association between paraoxonases gene expression and oxidative stress in hepatotoxicity induced by CCl4.Oxidative medicine and cellular longevity · 2014Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDicranopteris linearis (family Gleicheniaceae) has been reported to possess anti-inflammatory and antioxidant activities but no attempt has been made to study its hepatoprotective potential. The aim of the present study was to determine the hepatoprotective effect of methanol extracts of D. linearis (MEDL) against carbon tetrachloride (CCl4)-induced acute liver injury in rats.
methods6 groups (n = 6) of rats received oral test solutions: 10% dimethyl sulfoxide (DMSO), 200 mg/kg silymarin, or MEDL (50, 250, and 500 mg/kg), once daily for 7 consecutive days, followed by hepatotoxicity induction with CCl4. Blood and liver were collected for biochemical and microscopic analysis. The extract was also subjected to antioxidant studies (e.g. 2, 2-diphenyl-1-picrylhydrazyl (DPPH)- and superoxide anion-radical scavenging assays, oxygen radical absorbance capacity (ORAC) test and total phenolic content (TPC) determination), phytochemical screening and HPLC analysis.
resultsPretreatment with MEDL and silymarin significantly (P < 0.05) reduced the serum levels of AST, ALT and ALP, which were increased significantly (P < 0.05) in DMSO-pretreated group following treatment with CCl4. Histological analysis of liver tissues in groups pretreated with MEDL and silymarin showed mild necrosis and inflammation of the hepatocytes compared to the DMSO-pretreated group (negative control group). The MEDL showed higher DPPH- and superoxide anion-radical scavenging activity as well as high TPC and ORAC values indicating high antioxidant activity.
conclusionsMEDL exerts hepatoprotective activity that could be partly contributed by its antioxidant activity and high phenolic content, and hence demands further investigation.
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