ArticleClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2014
Grass-specific CD4(+) T-cells exhibit varying degrees of cross-reactivity, implications for allergen-specific immunotherapy.
Article in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed.
- Oral desensitization therapy for peanut allergy induces dynamic changes in peanut-specific immune responses.Allergy · 2022Trial
- Update about Oralair® as a treatment for grass pollen allergic rhinitis.Human vaccines & immunotherapeutics · 2022Review
- Th2A cells: The pathogenic players in allergic diseases.Frontiers in immunology · 2022Review
- Variability of grass pollen allergy symptoms throughout the season: Comparing symptom data profiles from the Patient's Hayfever Diary from 2014 to 2016 in Vienna (Austria).The World Allergy Organization journal · 2021Article
- Antigen-specific regulatory T-cell responses against aeroantigens and their role in allergy.Mucosal immunology · 2018Review
- Microbiota epitope similarity either dampens or enhances the immunogenicity of disease-associated antigenic epitopes.PloS one · 2018Article
- T-cell epitope conservation across allergen species is a major determinant of immunogenicity.The Journal of allergy and clinical immunology · 2016Article
- Ana o 1 and Ana o 2 cashew allergens share cross-reactive CD4(+) T cell epitopes with other tree nuts.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2016Article
- Jug r 2-reactive CD4(+) T cells have a dominant immune role in walnut allergy.The Journal of allergy and clinical immunology · 2015Article
- Immunological consequences of intragenus conservation of Mycobacterium tuberculosis T-cell epitopes.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Choosing the optimal dose in sublingual immunotherapy: Rationale for the 300 index of reactivity dose.Clinical and translational allergy · 2015Review
- Practical recommendations for mixing allergy immunotherapy extracts.Allergy & rhinology (Providence, R.I.) · 2015Article
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Abstract
backgroundConceptually, allergic responses may involve cross-reactivity by antibodies or T-cells. While IgE cross-reactivity among grass-pollen allergens has been observed, cross-reactivity at the allergen-specific T-cell level has been less documented. Identification of the patterns of cross-reactivity may improve our understanding, allowing optimization of better immunotherapy strategies.
objectivesWe use Phleum pratense as model for the studying of cross-reactivity at the allergen-specific CD4(+) T cell level among DR04:01 restricted Pooideae grass-pollen T-cell epitopes.
methodsAfter in vitro culture of blood mono-nucleated cells from grass-pollen-allergic subjects with specific Pooideae antigenic epitopes, dual tetramer staining with APC-labelled DR04:01/Phleum pratense tetramers and PE-labelled DR04:01/Pooideae grass homolog tetramers was assessed to identify cross-reactivity among allergen-specific DR04:01-restricted T-cells in six subjects. Direct ex vivo staining enabled the comparison of frequency and phenotype of different Pooideae grass-pollen reactive T-cells. Intracellular cytokine staining (ICS) assays were also used to examine phenotypes of these T-cells.
resultsT-cells with various degrees of cross-reactive profiles could be detected. Poa p 1 97-116 , Lol p 1 221-240 , Lol p 5a 199-218 , and Poa p 5a 199-218 were identified as minimally cross-reactive T-cell epitopes that do not show cross-reactivity to Phl p 1 and Phl p 5a epitopes. Ex vivo tetramer staining assays demonstrated T-cells that recognized these minimally cross-reactive T-cell epitopes are present in Grass-pollen-allergic subjects.
conclusionsOur results suggest that not all Pooideae grass epitopes with sequence homology are cross-reactive. Non-cross-reactive T-cells with comparable frequency, phenotype and functionality to Phl p-specific T-cells suggest that a multiple allergen system should be considered for immunotherapy instead of a mono-allergen system.
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