Evidence map›Paper›PMID 24708388›Full record

Trial reportClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2015

Dietary inflammatory index is related to asthma risk, lung function and systemic inflammation in asthma.

L G Wood, N Shivappa, B S Berthon, P G Gibson, J R Hebert

Abstract readClinical TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 153 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
153citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

153 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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  10. Dietary Inflammatory Index, Bone Mineral Density, and Risk of Fracture in Postmenopausal Women: Results From the Women's Health Initiative.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2017
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93 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

L G WoodCentre for Asthma and Respiratory Diseases, Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW, Australia.
N Shivappa
B S Berthon
P G Gibson
J R Hebert

Funding

Training ProgramU54CA153461 · NCI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI HEBERT, JAMES R · 2010 to 2015
$4.8M
South Carolina Cancer Disparities Community NetworksU01CA114601 · NCI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI HEBERT, JAMES R · 2005 to 2010
$3.8M
Diet & Activity Community Trial: High-Risk Colon PolypsR24MD002769 · NIMHD · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI HEBERT, JAMES R · 2008 to 2012
$2.8M
Expanding Mentoring Capacity in High-Risk PopulationsK05CA136975 · NCI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI HEBERT, JAMES R · 2009 to 2013
$801k
NCI NIH HHS K05 CA136975NCI NIH HHS U01 CA114601NCI NIH HHS U54 CA153461NIMHD NIH HHS R24 MD002769
6 · The paper itself

Abstract

backgroundAsthma prevalence has increased in recent years, and evidence suggests that diet may be a contributing factor. Increased use of processed foods has led to a decrease in diet quality, which may be creating a pro-inflammatory environment, thereby leading to the development and/or progression of various chronic inflammatory diseases and conditions. Recently, the dietary inflammatory index (DII) has been developed and validated to assess the inflammatory potential of individual diets.

objectiveThis study aimed to examine the DII in subjects with asthma compared to healthy controls and to relate the DII to asthma risk, lung function and systemic inflammation.

methodsSubjects with asthma (n = 99) and healthy controls (n = 61) were recruited. Blood was collected and spirometry was performed. The DII was calculated from food frequency questionnaires administered to study subjects.

resultsThe mean DII score for the asthmatics was higher than the mean DII score for healthy controls (- 1.40 vs. - 1.86, P = 0.04), indicating that their diets were more pro-inflammatory. For every 1 unit increase in DII score, the odds of having asthma increased by 70% (OR: 1.70, 95% CI: 1.03, 2.14; P = 0.040). FEV1 was significantly associated with DII score (β = - 3.44, 95% CI: - 6.50, - 0.39; P = 0.020), indicating that for every 1 unit increase in DII score, FEV1 decreased by 3.44 times. Furthermore, plasma IL-6 concentrations were positively associated with DII score (β = 0.13, 95% CI: 0.05, 0.21; P = 0.002). CONCLUSION AND CLINICAL RELEVANCE: As assessed using the DII score, the usual diet consumed by asthmatics in this study was pro-inflammatory relative to the diet consumed by the healthy controls. The DII score was associated with increased systemic inflammation and lower lung function. Hence, consumption of pro-inflammatory foods may contribute to worse asthma status, and targeting an improvement in DII in asthmatics, as an indicator of suitable dietary intake, might be a useful strategy for improving clinical outcomes in the disease.

Indexed as

AsthmaFood QualityAdultDietFemaleFollow-Up StudiesHumansInflammationInflammation MediatorsMaleMiddle AgedRespiratory Function TestsInflammation Mediatorsasthmadietinflammation

Identifiers

PMID24708388
PMCPMC4190104

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.