ReviewBehavioral neuroscience2014
The development of sleep-wake rhythms and the search for elemental circuits in the infant brain.
Review in Behavioral neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 101 citations in OpenAlex.
- Trial
- Associations Between Breast Milk Energy Intake, Infant Sleep Duration and Time Until Next Feed.Clocks & sleep · 2026Article
- Assessing infants' sleep in the home setting: designing rational study approaches.Pediatric research · 2026Review
- How Are Sleep, Settle, and Crying Behaviors in 2-Month-Olds Related to Concurrent Family Factors and Later Development?Developmental science · 2026Article
- The Ontogenetic Development of Rapid Eye Movement Sleep in Early Life and Its Regulatory Mechanisms.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2026Review
- The ventrolateral preoptic nucleus: a multisystem integrator in sleep-wake regulation.Frontiers in neuroscience · 2026Review
- Article
- A switch in arousal circuit architecture shapes sleep across the lifespan.bioRxiv : the preprint server for biology · 2025Article
- Postnatal choline supplementation improves sleep in a rat model of developmental alcohol exposure.Alcohol, clinical & experimental research · 2025Article
- The neurobiology of parenting and infant-evoked aggression.Physiological reviews · 2025Review
- Sleep as a driver of pre- and postnatal brain development.Pediatric research · 2024Review
- Mapping the physiological changes in sleep regulation across infancy and young childhood.PLoS computational biology · 2024Article
- Article
- Review
- Energetic Demands Regulate Sleep-Wake Rhythm Circuit Development.bioRxiv : the preprint server for biology · 2024Article
- Bruxism associated with short sleep duration in children with autism spectrum disorder: The Japan Environment and Children's Study.PloS one · 2024Article
- Developmental emergence of sleep rhythms enables long-term memory inScience advances · 2023Article
- Arousal state transitions occlude sensory-evoked neurovascular coupling in neonatal mice.Communications biology · 2023Article
- Ontogenesis of the molecular response to sleep loss.Neurobiology of sleep and circadian rhythms · 2023Article
- Ontogenesis of the molecular response to sleep loss.bioRxiv : the preprint server for biology · 2023Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Despite the predominance of sleep in early infancy, developmental science has yet to play a major role in shaping concepts and theories about sleep and its associated ultradian and circadian rhythms. Here we argue that developmental analyses help us to elucidate the relative contributions of the brainstem and forebrain to sleep-wake control and to dissect the neural components of sleep-wake rhythms. Developmental analysis also makes it clear that sleep-wake processes in infants are the foundation for those of adults. For example, the infant brainstem alone contains a fundamental sleep-wake circuit that is sufficient to produce transitions among wakefulness, quiet sleep, and active sleep. In addition, consistent with the requirements of a "flip-flop" model of sleep-wake processes, this brainstem circuit supports rapid transitions between states. Later in development, strengthening bidirectional interactions between the brainstem and forebrain contribute to the consolidation of sleep and wake bouts, the elaboration of sleep homeostatic processes, and the emergence of diurnal or nocturnal circadian rhythms. The developmental perspective promoted here critically constrains theories of sleep-wake control and provides a needed framework for the creation of fully realized computational models. Finally, with a better understanding of how this system is constructed developmentally, we will gain insight into the processes that govern its disintegration due to aging and disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.