ReviewJournal of bone metabolism2014
Should we prescribe calcium supplements for osteoporosis prevention?
Review in Journal of bone metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 54 citations in OpenAlex.
- Bone loss after oophorectomy among high-risk women: an NRG oncology/gynecologic oncology group study.Menopause (New York, N.Y.) · 2016Trial
- Two-year outcomes of denosumab treatment for osteoporosis comparing the effects of calcium and vitamin D supplementation.Scientific reports · 2025Article
- Autoimmune protocol diet: A personalized elimination diet for patients with autoimmune diseases.Metabolism open · 2025Review
- Total, dietary, and supplemental calcium intake and risk of all-cause, cardiovascular, and cancer mortality among U.S. adults: a prospective cohort study from the National Health and Nutrition Examination Survey.Archives of osteoporosis · 2024Article
- Bio-Calcium from Skipjack Tuna Frame Attenuates Bone Loss in Ovariectomy-Induced Osteoporosis Rats.Marine drugs · 2024Article
- Prevalence of osteoporosis and associated factors among people aged 50 years and older in the Madhesh province of Nepal: a community-based cross-sectional study.Journal of health, population, and nutrition · 2024Article
- Effect of 50-Hertz Sinusoidal Vibration on the Uterus in Ovariectomy-Induced Osteoporotic Rats.Computational and mathematical methods in medicine · 2022Article
- Effects of preventive nutrition interventions among adolescents on health and nutritional status in low- and middle-income countries: A systematic review.Campbell systematic reviews · 2020Review
- Evodiamine inhibits RANKL-induced osteoclastogenesis and prevents ovariectomy-induced bone loss in mice.Journal of cellular and molecular medicine · 2019Article
- Clinical Management of Osteoporotic Fractures.Current osteoporosis reports · 2018Review
- PROTOCOL: Effects of preventive nutrition interventions among adolescents on health and nutritional status in low- and middle-income countries: a systematic review.Campbell systematic reviews · 2018Article
- The good, the bad, and the ugly of calcium supplementation: a review of calcium intake on human health.Clinical interventions in aging · 2018Review
- Osteoporosis: a discussion on the past 5 years.Current reviews in musculoskeletal medicine · 2017Review
- Coronary Calcification Is Reversely Related with Bone and Hair Calcium: The Relationship among Different Calcium Pools in Body.Journal of bone metabolism · 2016Article
- Osteoporosis: Modern Paradigms for Last Century's Bones.Nutrients · 2016Review
- Biocompatibility of magnesium implants in primary human reaming debris-derived cells stem cells in vitro.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2016Article
- Effect of serum from postmenopausal women with osteoporosis exhibiting the Kidney-Yang deficiency pattern on bone formation in an hFOB 1.19 human osteoblastic cell line.Experimental and therapeutic medicine · 2015Article
- A practical approach to osteoporosis management in the geriatric population.Canadian geriatrics journal : CGJ · 2015Article
- Vitamin D, Essential Minerals, and Toxic Elements: Exploring Interactions between Nutrients and Toxicants in Clinical Medicine.TheScientificWorldJournal · 2015Review
- The role of calcium in human aging.Clinical nutrition research · 2015Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Advocacy for the use of calcium supplements arose at a time when there were no other effective interventions for the prevention of osteoporosis. Their promotion was based on the belief that increasing calcium intake would increase bone formation. Our current understandings of the biology of bone suggest that this does not occur, though calcium does act as a weak antiresorptive. Thus, it slows postmenopausal bone loss but, despite this, recent meta-analyses suggest no significant prevention of fractures. In sum, there is little substantive evidence of benefit to bone health from the use of calcium supplements. Against this needs to be balanced the likelihood that calcium supplement use increases cardiovascular events, kidney stones, gastrointestinal symptoms, and admissions to hospital with acute gastrointestinal problems. Thus, the balance of risk and benefit seems to be consistently negative. As a result, current recommendations are to obtain calcium from the diet in preference to supplements. Dietary calcium intake has not been associated with the adverse effects associated with supplements, probably because calcium is provided in smaller boluses, which are absorbed more slowly since they come together with quantities of protein and fat, resulting in a slower gastric transit time. These findings suggest that calcium supplements have little role to play in the modern therapeutics of osteoporosis, which is based around the targeting of safe and effective anti-resorptive drugs to individuals demonstrated to be at increased risk of future fractures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.