Evidence map›Paper›PMID 24707343›Full record

ArticleOxidative medicine and cellular longevity2014

Sulforaphane attenuation of type 2 diabetes-induced aortic damage was associated with the upregulation of Nrf2 expression and function.

Yonggang Wang, Zhiguo Zhang, Wanqing Sun, Yi Tan, Yucheng Liu, Yang Zheng, Quan Liu, Lu Cai, Jian Sun

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oxidative medicine and cellular longevity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 78 citations in OpenAlex.

  1. Review
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  9. Article
  10. Article
  11. Protective role of NRF2 in macrovascular complications of diabetes.Journal of cellular and molecular medicine · 2020
    Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Endothelial Cell Metabolism.Physiological reviews · 2018
    Review
  18. Broccoli (Preventive nutrition and food science · 2017
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Yonggang WangCardiovascular Center at the First Hospital of Jilin University, 71 Xinmin Street, Changchun 130021, China ; Kosair Children's Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA.
Zhiguo ZhangCardiovascular Center at the First Hospital of Jilin University, 71 Xinmin Street, Changchun 130021, China ; Kosair Children's Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA.
Wanqing SunCardiovascular Center at the First Hospital of Jilin University, 71 Xinmin Street, Changchun 130021, China.
Yi TanKosair Children's Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA ; The Chinese-American Research Institute, Wenzhou Medical University, Wenzhou 325035, China ; Departments of Radiation Oncology, Pharmacology and Toxicology, University of Louisville, Louisville, KY 40292, USA.
Yucheng LiuKosair Children's Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA.
Yang ZhengCardiovascular Center at the First Hospital of Jilin University, 71 Xinmin Street, Changchun 130021, China.
Quan LiuCardiovascular Center at the First Hospital of Jilin University, 71 Xinmin Street, Changchun 130021, China.
Lu CaiKosair Children's Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA ; The Chinese-American Research Institute, Wenzhou Medical University, Wenzhou 325035, China ; Departments of Radiation Oncology, Pharmacology and Toxicology, University of Louisville, Louisville, KY 40292, USA.
Jian SunCardiovascular Center at the First Hospital of Jilin University, 71 Xinmin Street, Changchun 130021, China.
Jilin University · CNUniversity of Louisville · USFirst Hospital of Jilin University · CNKosair Children's Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Type 2 diabetes mellitus (T2DM) significantly increases risk for vascular complications. Diabetes-induced aorta pathological changes are predominantly attributed to oxidative stress. Nuclear factor E2-related factor-2 (Nrf2) is a transcription factor orchestrating antioxidant and cytoprotective responses to oxidative stress. Sulforaphane protects against oxidative damage by increasing Nrf2 expression and its downstream target genes. Here we explored the protective effect of sulforaphane on T2DM-induced aortic pathogenic changes in C57BL/6J mice which were fed with high-fat diet for 3 months, followed by a treatment with streptozotocin at 100 mg/kg body weight. Diabetic and nondiabetic mice were randomly divided into groups with and without 4-month sulforaphane treatment. Aorta of T2DM mice exhibited significant increases in the wall thickness and structural derangement, along with significant increases in fibrosis (connective tissue growth factor and transforming growth factor), inflammation (tumor necrosis factor-α and vascular cell adhesion molecule 1), oxidative/nitrative stress (3-nitrotyrosine and 4-hydroxy-2-nonenal), apoptosis, and cell proliferation. However, these pathological changes were significantly attenuated by sulforaphane treatment that was associated with a significant upregulation of Nrf2 expression and function. These results suggest that sulforaphane is able to upregulate aortic Nrf2 expression and function and to protect the aorta from T2DM-induced pathological changes.

Indexed as

AnimalsAortaApoptosisCell ProliferationDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2FibrosisInflammationIsothiocyanatesMaleMiceMice, Inbred C57BLNF-E2-Related Factor 2Oxidative StressProtective AgentsSignal TransductionIsothiocyanatesNF-E2-Related Factor 2Protective AgentssulforaphaneSulfoxides

Identifiers

PMID24707343
PMCPMC3953421
OpenAlexW2018797572

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.