ArticleLaboratory animal research2014
Perilla oil improves blood flow through inhibition of platelet aggregation and thrombus formation.
Article in Laboratory animal research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Trial
- Perilla Seed Oil: A Review of Health Effects, Encapsulation Strategies and Applications in Food.Foods (Basel, Switzerland) · 2024Review
- A comprehensive review on nutritional, nutraceutical, and industrial perspectives of perilla (Heliyon · 2024Review
- Perilla oil and α-linolenic acid ameliorated thrombosis in rats induced by collagen and epinephrine.Food science and biotechnology · 2023Article
- DK-MGAR101, an extract of adventitious roots of mountain ginseng, improves blood circulation by inhibiting endothelial cell injury, platelet aggregation, and thrombus formation.Journal of ginseng research · 2022Article
- Effects of Baru Almond Oil (Nutrients · 2022Article
- Analgesic, anti-inflammatory and anti-ulcer properties of Thai Perilla frutescence fruit oil in animals.Bioscience reports · 2021Article
- Timing of Heparin Administration Modulates Arterial Occlusive Thrombotic Response in Rats.Journal of cardiovascular development and disease · 2020Article
- Evidence Supporting a Phased Immuno-physiological Approach to COVID-19 From Prevention Through Recovery.Integrative medicine (Encinitas, Calif.) · 2020Review
- Comparative anti-thrombotic activity and haemorrhagic adverse effect of nattokinase and tissue-type plasminogen activator.Food science and biotechnology · 2019Article
- PDK1 governs thromboxane generation and thrombosis in platelets by regulating activation of Raf1 in the MAPK pathway.Journal of thrombosis and haemostasis : JTH · 2018Article
- Protective effects of perilla oil and alpha linolenic acid on SH-SY5Y neuronal cell death induced by hydrogen peroxide.Nutrition research and practice · 2018Article
- Blood flow-improving activity of methyl jasmonate-treated adventitious roots of mountain ginseng.Laboratory animal research · 2017Article
- Comparative effects of plant oils and trans-fat on blood lipid profiles and ischemic stroke in rats.Journal of biomedical research · 2017Article
- Article
- Anti-atherosclerotic effects of perilla oil in rabbits fed a high-cholesterol diet.Laboratory animal research · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The inhibitory effects of perilla oil on the platelet aggregation in vitro and thrombosis in vivo were investigated in comparison with aspirin, a well-known blood flow enhancer. Rabbit platelet-rich plasma was incubated with perilla oil and aggregation inducers collagen or thrombin, and the platelet aggregation rate was analyzed. Perilla oil significantly inhibited both the collagen- and thrombin-induced platelet aggregations, in which the thromboxane B2 formation from collagen-activated platelets were reduced in a concentration-dependent manner. Rats were administered once daily by gavage with perilla oil for 1 week, carotid arterial thrombosis was induced by applying 35% FeCl3-soaked filter paper for 10 min, and the blood flow was monitored with a laser Doppler probe. Perilla oil delayed the FeCl3-induced arterial occlusion in a dose-dependent manner, doubling the occlusion time at 0.5 mL/kg. In addition, a high dose (2 mL/kg) of perilla oil greatly prevented the occlusion, comparable to the effect of aspirin (30 mg/kg). The results indicate that perilla oil inhibit platelet aggregation by blocking thromboxane formation, and thereby delay thrombosis following oxidative arterial wall injury. Therefore, it is proposed that perilla oil could be a good candidate without adverse effects for the improvement of blood flow.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.