ArticleMediators of inflammation2014
Regulation of NAMPT in human gingival fibroblasts and biopsies.
Article in Mediators of inflammation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Pooled it
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- Expression of visfatin in gingival crevicular fluid and gingival tissues in different periodontal conditions: a cross-sectional study.BMC oral health · 2024Article
- Obesity and Oral Health: The Link Between Adipokines and Periodontitis.TouchREVIEWS in endocrinology · 2024Review
- The impact ofFrontiers in dental medicine · 2024Review
- Gingival crevicular fluid levels of apelin correlates with clinical periodontal diagnosis.Clinical oral investigations · 2023Article
- Genome-Wide Analysis of Dental Caries Variability Reveals Genotype-by-Environment Interactions.Genes · 2023Article
- Apelin Enhances the Effects ofInternational journal of molecular sciences · 2023Article
- Overexpression of DEL-1 Downregulates SH3BP2 Expression and Inhibits Porphyromonas gingivalis-induced Gingival Inflammation In Vivo and In Vitro.Oral health & preventive dentistry · 2022Article
- The human oral virome: Shedding light on the dark matter.Periodontology 2000 · 2021Review
- Evaluation of adipokines and inflammatory mediator expression levels in patients with periodontitis and peri-implantitis: a cross-sectional study.Clinical oral investigations · 2021Article
- Article
- Regulation of Anti-Apoptotic SOD2 and BIRC3 in Periodontal Cells and Tissues.International journal of molecular sciences · 2021Article
- Regulation of matrix metalloproteinase-1 by Filifactor alocis in human gingival and monocytic cells.Clinical oral investigations · 2020Article
- Resistin Is Increased in Periodontal Cells and Tissues:Mediators of inflammation · 2020Article
- Regulation of Cyclooxygenase 2 byMediators of inflammation · 2020Article
- Characterization of a diet-induced obesity rat model for periodontal research.Clinical oral investigations · 2019Article
- Regulation of somatostatin receptor 2 by proinflammatory, microbial and obesity-related signals in periodontal cells and tissues.Head & face medicine · 2019Article
- Damage-regulated autophagy modulator 1 in oral inflammation and infection.Clinical oral investigations · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adipokines, such as nicotinamide phosphoribosyltransferase (NAMPT), are molecules, which are produced in adipose tissue. Recent studies suggest that NAMPT might also be produced in the tooth-supporting tissues, that is, periodontium, which also includes the gingiva. The aim of this study was to examine if and under what conditions NAMPT is produced in gingival fibroblasts and biopsies from healthy and inflamed gingiva. Gingival fibroblasts produced constitutively NAMPT, and this synthesis was significantly increased by interleukin-1β and the oral bacteria P. gingivalis and F. nucleatum. Inhibition of the MEK1/2 and NFκB pathways abrogated the stimulatory effects of F. nucleatum on NAMPT. Furthermore, the expression and protein levels of NAMPT were significantly enhanced in gingival biopsies from patients with periodontitis, a chronic inflammatory infectious disease of the periodontium, as compared to gingiva from periodontally healthy individuals. In summary, the present study provides original evidence that gingival fibroblasts produce NAMPT and that this synthesis is increased under inflammatory and infectious conditions. Local synthesis of NAMPT in the inflamed gingiva may contribute to the enhanced gingival and serum levels of NAMPT, as observed in periodontitis patients. Moreover, local production of NAMPT by gingival fibroblasts may represent a possible mechanism whereby periodontitis may impact on systemic diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.