Evidence map›Paper›PMID 24707116›Full record

ArticleMediators of inflammation2014

Immunoregulatory effects of bone marrow-derived mesenchymal stem cells in the nasal polyp microenvironment.

Rogério Pezato, Danilo Cândido de Almeida, Thiago Freire Bezerra, Fernando de Sá Silva, Claudina Perez-Novo, Luís Carlos Gregório, Richard Louis Voegels, Niels Olsen Câmara, Claus Bachert

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mediators of inflammation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 28 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Review
  5. Differential Angiogenic Induction Impacts Nasal Polyp Tissue Growth.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023
    Article
  6. Article
  7. Review
  8. Article
  9. BMP-7, MMP-9, and TGF-β tissue remodeling proteins and their correlations with interleukins 6 and 10 in chronic rhinosinusitis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021
    Observational
  10. Article
  11. Application of Mesenchymal Stem Cells in Inflammatory and Fibrotic Diseases.International journal of molecular sciences · 2020
    Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Rogério PezatoUpper Airway Research Laboratory (URL), Department of Otorhinolaryngology, Ghent University Hospital, Ghent University, 9000 Ghent, Belgium ; Department of Otolaryngology-Head and Neck Surgery, Federal University of São Paulo, Rua dos Otonis, 700 Piso Superior, Vila Clementino, 04025-002 São Paulo, SP, Brazil.
Danilo Cândido de AlmeidaNephrology Division, Department of Medicine, Federal University of São Paulo, 04025-002 São Paulo, SP, Brazil.
Thiago Freire BezerraDepartment of Otorhinolaryngology and Ophthalmology, University of São Paulo, 05508-070 São Paulo, SP, Brazil.
Fernando de Sá SilvaDepartment of Immunology, Institute of Biomedical Sciences IV, University of São Paulo, 05508-070 São Paulo, SP, Brazil.
Claudina Perez-NovoUpper Airway Research Laboratory (URL), Department of Otorhinolaryngology, Ghent University Hospital, Ghent University, 9000 Ghent, Belgium.
Luís Carlos GregórioDepartment of Otolaryngology-Head and Neck Surgery, Federal University of São Paulo, Rua dos Otonis, 700 Piso Superior, Vila Clementino, 04025-002 São Paulo, SP, Brazil.
Richard Louis VoegelsDepartment of Otorhinolaryngology and Ophthalmology, University of São Paulo, 05508-070 São Paulo, SP, Brazil.
Niels Olsen CâmaraDepartment of Immunology, Institute of Biomedical Sciences IV, University of São Paulo, 05508-070 São Paulo, SP, Brazil.
Claus BachertUpper Airway Research Laboratory (URL), Department of Otorhinolaryngology, Ghent University Hospital, Ghent University, 9000 Ghent, Belgium.
Universidade de São Paulo · BRUniversidade Federal de São Paulo · BRGhent University Hospital · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nasal polyposis is a severe, chronic inflammatory condition of the paranasal sinuses and is frequently associated with asthma and aspirin sensitivity. Mesenchymal stem cells exhibit a potent immunosuppressive effect in several inflammatory conditions, and their role in nasal polyposis remains little explored. Hence, we investigated whether bone marrow-derived mesenchymal stem cells could modulate cell phenotype in the nasal polyp milieu. After coculture with mesenchymal stem cells, the frequency of these inflammatory cells was found to decrease. Furthermore, mesenchymal stem cells promoted strong inhibition of CD4+ and CD8+ T cell proliferation, increased the frequency of CD4+CD25+Foxp3 T cells, and changed the global cytokine profile from an inflammatory to an anti-inflammatory response. We believe that mesenchymal stem cells may be a very useful adjunct for investigation of the inflammatory process in nasal polyposis, contributing to better understanding of the inflammatory course of this condition.

Indexed as

Gene Expression RegulationBone Marrow CellsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCells, CulturedCoculture TechniquesCytokinesForkhead Transcription FactorsHumansInflammationLymphocyte ActivationMesenchymal Stem CellsNasal PolypsPhenotypeCytokinesForkhead Transcription FactorsFOXP3 protein, human

Identifiers

PMID24707116
PMCPMC3943259
OpenAlexW1998405597

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.