ArticleJournal of cell science2014
Cytokinesis defines a spatial landmark for hepatocyte polarization and apical lumen formation.
Article in Journal of cell science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed.
- Centrosome migration and apical membrane formation during epithelial polarization in MDCK cysts.eLife · 2026Article
- E- and N-cadherin drive hepatic polarity and lumen elongation via opposing effects on RhoA activity.The Journal of cell biology · 2026Article
- PAR3-mediated coordination of hepatocyte proliferation, maturation, and architecture in liver development and regeneration.Nature communications · 2026Article
- E- and N-cadherin drive hepatic polarity and lumen elongation via opposing effects on RhoA activity.bioRxiv : the preprint server for biology · 2025Article
- Contractile ring mechanosensation and its anillin-dependent tuning during early embryogenesis.Nature communications · 2023Article
- Cholesterol-rich domain formation mediated by ZO proteins is essential for tight junction formation.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- E-cadherin mediates apical membrane initiation site localisation during de novo polarisation of epithelial cavities.The EMBO journal · 2022Article
- PHLPP1 regulates CFTR activity and lumen expansion through AMPK.Development (Cambridge, England) · 2022Article
- New signaling kid on the block: the role of the postmitotic midbody in polarity, stemness, and proliferation.Molecular biology of the cell · 2022Review
- Anisotropic expansion of hepatocyte lumina enforced by apical bulkheads.The Journal of cell biology · 2021Article
- CD13 orients the apical-basal polarity axis necessary for lumen formation.Nature communications · 2021Article
- Rab22a regulates the establishment of epithelial polarity.Small GTPases · 2021Article
- Biomimetic niches reveal the minimal cues to trigger apical lumen formation in single hepatocytes.Nature materials · 2020Article
- Fast and efficient generation of knock-in human organoids using homology-independent CRISPR-Cas9 precision genome editing.Nature cell biology · 2020Article
- Aurora B functions at the apical surface after specialized cytokinesis during morphogenesis inDevelopment (Cambridge, England) · 2020Article
- The postmitotic midbody: Regulating polarity, stemness, and proliferation.The Journal of cell biology · 2019Review
- Midbody: From the Regulator of Cytokinesis to Postmitotic Signaling Organelle.Medicina (Kaunas, Lithuania) · 2018Review
- Insane in the apical membrane: Trafficking events mediating apicobasal epithelial polarity during tube morphogenesis.Traffic (Copenhagen, Denmark) · 2018Review
- Rab GTPases and cell division.Small GTPases · 2018Review
- IFT proteins spatially control the geometry of cleavage furrow ingression and lumen positioning.Nature communications · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
By definition, all epithelial cells have apical-basal polarity, but it is unclear how epithelial polarity is acquired and how polarized cells engage in tube formation. Here, we show that hepatocyte polarization is linked to cytokinesis using the rat hepatocyte cell line Can 10. Before abscission, polarity markers are delivered to the site of cell division in a strict spatiotemporal order. Immediately after abscission, daughter cells remain attached through a unique disc-shaped structure, which becomes the site for targeted exocytosis, resulting in the formation of a primitive bile canaliculus. Subsequently, oriented cell division and asymmetric cytokinesis occur at the bile canaliculus midpoint, resulting in its equal partitioning into daughter cells. Finally, successive cycles of oriented cell division and asymmetric cytokinesis lead to the formation of a tubular bile canaliculus, which is shared by two rows of hepatocytes. These findings define a novel mechanism for cytokinesis-linked polarization and tube formation, which appears to be broadly conserved in diverse cell types.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.