ArticleProceedings of the National Academy of Sciences of the United States of America2014
Two-photon excitation improves multifocal structured illumination microscopy in thick scattering tissue.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed.
- Double-helix optical point spread function enables real-time mesoscopic 3D functional microangiography in the living mouse brain and skull.Nature communications · 2026Article
- Advanced Microscopy Techniques.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026Review
- Deep3DSIM: Super-resolution imaging of thick tissue using 3D structured illumination with adaptive optics.eLife · 2025Article
- Super-resolution upgrade for deep tissue imaging featuring simple implementation.Nature communications · 2025Article
- Super-resolution microscopy based on the inherent fluctuations of dye molecules.Biomedical optics express · 2025Article
- Optical sectioning methods in three-dimensional bioimaging.Light, science & applications · 2025Review
- Mechanical-scan-free multicolor super-resolution imaging with diffractive spot array illumination.Nature communications · 2024Article
- Deep-MSIM: Fast Image Reconstruction with Deep Learning in Multifocal Structured Illumination Microscopy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Superresolution structured illumination microscopy reconstruction algorithms: a review.Light, science & applications · 2023Review
- Combined alteration of lamin and nuclear morphology influences the localization of the tumor-associated factor AKTIP.Journal of experimental & clinical cancer research : CR · 2022Article
- Super-resolution microscopy: a brief history and new avenues.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2022Article
- Technological advances in super-resolution microscopy to study cellular processes.Molecular cell · 2022Review
- HiLo Based Line Scanning Temporal Focusing Microscopy for High-Speed, Deep Tissue Imaging.Membranes · 2021Article
- AKTIP interacts with ESCRT I and is needed for the recruitment of ESCRT III subunits to the midbody.PLoS genetics · 2021Article
- Review of bio-optical imaging systems with a high space-bandwidth product.Advanced photonics · 2021Article
- Improving axial resolution in Structured Illumination Microscopy using deep learning.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2021Article
- Super-resolution structured illumination microscopy: past, present and future.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2021Article
- Super-resolution fluorescence microscopy by line-scanning with an unmodified two-photon microscope.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2021Article
- Axial resolution improvement of two-photon microscopy by multi-frame reconstruction and adaptive optics.Biomedical optics express · 2020Article
- Multiphoton microscopy: a personal historical review, with some future predictions.Journal of biomedical optics · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Multifocal structured illumination microscopy (MSIM) provides a twofold resolution enhancement beyond the diffraction limit at sample depths up to 50 µm, but scattered and out-of-focus light in thick samples degrades MSIM performance. Here we implement MSIM with a microlens array to enable efficient two-photon excitation. Two-photon MSIM gives resolution-doubled images with better sectioning and contrast in thick scattering samples such as Caenorhabditis elegans embryos, Drosophila melanogaster larval salivary glands, and mouse liver tissue.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.