ArticleProceedings of the National Academy of Sciences of the United States of America2014
Genome sequencing of disease and carriage isolates of nontypeable Haemophilus influenzae identifies discrete population structure.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
73 citing papers in PubMed, 119 citations in OpenAlex.
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- A bacterial pangenome association study identifies a role for polyamine metabolism and alkaline tolerance in middle ear infections.PLoS pathogens · 2026Article
- Whole-genome and pan-genome analyses reveal genomic differences among nontypeableFrontiers in cellular and infection microbiology · 2026Article
- Haemophilus influenzae and Staphylococcus aureus population shifts during social distancing as monitored by MALDI-TOF MS.Scientific reports · 2025Article
- Genetic population structure of Haemophilus influenzae at local and global scales.Nature microbiology · 2025Article
- Molecular insights into pangenome localization and constructs design for Hemophilus influenza vaccine.Scientific reports · 2025Article
- Intra-host genomic variation of serologically nontypeableMicrobiology spectrum · 2025Article
- Nasal vaccines for respiratory infections.Nature · 2025Review
- Genomic profiling of cefotaxime-resistantFrontiers in microbiology · 2025Article
- Comparative genomic study of non-typeableiScience · 2024Article
- Development and implementation of a core genome multilocus sequence typing scheme forMicrobial genomics · 2024Article
- Convergent impact of vaccination and antibiotic pressures on pneumococcal populations.Cell chemical biology · 2024Review
- Genome Characterisation of InvasivePathogens (Basel, Switzerland) · 2023Article
- A Robust Protocol to Isolate Outer Membrane Vesicles from NontypeableMethods and protocols · 2023Article
- Can non-typeablePediatric investigation · 2023Article
- Genetic Adaptation and Acquisition of Macrolide Resistance in Haemophilus spp. during Persistent Respiratory Tract Colonization in Chronic Obstructive Pulmonary Disease (COPD) Patients Receiving Long-Term Azithromycin Treatment.Microbiology spectrum · 2023Article
- Epidemic Trends and Biofilm Formation Mechanisms of Haemophilus influenzae: Insights into Clinical Implications and Prevention Strategies.Infection and drug resistance · 2023Review
- The natural history and genetic diversity of Haemophilus influenzae infecting the airways of adults with cystic fibrosis.Scientific reports · 2022Article
- Comparative pangenome analysis of capsulated Haemophilus influenzae serotype f highlights their high genomic stability.Scientific reports · 2022Article
- An invasive Haemophilus influenzae serotype b infection in an Anglo-Saxon plague victim.Genome biology · 2022Article
13 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors at 6 institutions in 4 countries.
Funding
Abstract
One of the main hurdles for the development of an effective and broadly protective vaccine against nonencapsulated isolates of Haemophilus influenzae (NTHi) lies in the genetic diversity of the species, which renders extremely difficult the identification of cross-protective candidate antigens. To assess whether a population structure of NTHi could be defined, we performed genome sequencing of a collection of diverse clinical isolates representative of both carriage and disease and of the diversity of the natural population. Analysis of the distribution of polymorphic sites in the core genome and of the composition of the accessory genome defined distinct evolutionary clades and supported a predominantly clonal evolution of NTHi, with the majority of genetic information transmitted vertically within lineages. A correlation between the population structure and the presence of selected surface-associated proteins and lipooligosaccharide structure, known to contribute to virulence, was found. This high-resolution, genome-based population structure of NTHi provides the foundation to obtain a better understanding, of NTHi adaptation to the host as well as its commensal and virulence behavior, that could facilitate intervention strategies against disease caused by this important human pathogen.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.