ArticleProceedings of the National Academy of Sciences of the United States of America2014
Medicago truncatula symbiotic peptide NCR247 contributes to bacteroid differentiation through multiple mechanisms.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers.
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Who cites it
88 citing papers in PubMed, 178 citations in OpenAlex.
- A Chickpea NCR Peptide Suppresses Postharvest Alternaria alternata Infection by Disrupting Fungal Membranes, Mitochondria and Respiration.Molecular plant pathology · 2026Article
- Developmental fates and N2-fixing efficiency of terminally-differentiated versus undifferentiated bacteroids from legume nodules.Plant physiology · 2026Article
- BacA(SbmA) importer of legume symbiotic NCR peptides: Protein architecture, function, and evolutionary implications.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Article
- A plant-derived antimicrobial peptide with multiple mechanisms of action exhibiting antibacterial and antibiofilm activities comparable to or superior to polymyxin B.Current research in microbial sciences · 2026Article
- Exploiting peptide chirality and transport to dissect the complex mechanism of action of host peptides on bacteria.PLoS genetics · 2025Article
- Uclacyanin MtUC1 Is Involved in the Regulation of Nodule Senescence in Medicago truncatula.Molecular plant pathology · 2025Article
- Exploiting Peptide Chirality and Transport to Dissect the Complex Mechanism of Action of Host Peptides on Bacteria.bioRxiv : the preprint server for biology · 2025Article
- Bioactive Plant Peptides: Physicochemical Features, Structure-Function Insights and Mechanism of Action.Molecules (Basel, Switzerland) · 2025Review
- Protein import into bacterial endosymbionts and evolving organelles.The FEBS journal · 2025Review
- Taxonomic distribution of SbmA/BacA and BacA-like antimicrobial peptide transporters suggests independent recruitment and convergent evolution in host-microbe interactions.Microbial genomics · 2025Article
- Article
- Diurnal Rhythmicity in the Rhizosphere Microbiome-Mechanistic Insights and Significance for Rhizosphere Function.Plant, cell & environment · 2025Review
- A microaerobically induced small heat shock protein contributes toApplied and environmental microbiology · 2025Article
- The Small Key to the Treasure Chest: Endogenous Plant Peptides Involved in Symbiotic Interactions.Plants (Basel, Switzerland) · 2025Review
- Antagonism within mutualism: host control of symbionts through nodule-specific antimicrobial peptides.Frontiers in microbiology · 2025Review
- Plant-derived nodule-specific cysteine-rich peptides as potent antifungal agents againstCurrent research in microbial sciences · 2025Article
- Chickpea NCR13 disulfide cross-linking variants exhibit profound differences in antifungal activity and modes of action.PLoS pathogens · 2024Article
- TheJournal of bacteriology · 2024Article
- Modes of action and potential as a peptide-based biofungicide of a plant defensin MtDef4.Molecular plant pathology · 2024Article
28 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Symbiosis between rhizobia soil bacteria and legume plants results in the formation of root nodules where plant cells are fully packed with nitrogen fixing bacteria. In the host cells, the bacteria adapt to the intracellular environment and gain the ability for nitrogen fixation. Depending on the host plants, the symbiotic fate of bacteria can be either reversible or irreversible. In Medicago and related legume species, the bacteria undergo a host-directed multistep differentiation process culminating in the formation of elongated and branched polyploid bacteria with definitive loss of cell division ability. The plant factors are nodule-specific symbiotic peptides. Approximately 600 of them are nodule-specific cysteine-rich (NCR) peptides produced in the rhizobium-infected plant cells. NCRs are targeted to the endosymbionts, and concerted action of different sets of peptides governs different stages of endosymbiont maturation, whereas the symbiotic function of individual NCRs is unknown. This study focused on NCR247, a cationic peptide exhibiting in vitro antimicrobial activities. We show that NCR247 acts in those nodule cells where bacterial cell division is arrested and cell elongation begins. NCR247 penetrates the bacteria and forms complexes with many bacterial proteins. Interaction with FtsZ required for septum formation is one of the host interventions for inhibiting bacterial cell division. Complex formation with the ribosomal proteins affects translation and contributes to altered proteome and physiology of the endosymbiont. Binding to the chaperone GroEL amplifies the NCR247-modulated biological processes. We show that GroEL1 of Sinorhizobium meliloti is required for efficient infection, terminal differentiation, and nitrogen fixation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.