ArticleProceedings of the National Academy of Sciences of the United States of America2014
Optogenetic control of selective neural activity in multiple freely moving Drosophila adults.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- Recent social experience alters song behavior in Drosophila.Current biology : CB · 2026Article
- YORU: Animal behavior detection with object-based approach for real-time closed-loop feedback.Science advances · 2026Article
- Article
- The Roles of Optogenetics and Technology in Neurobiology: A Review.Frontiers in aging neuroscience · 2022Review
- A high-throughput method to deliver targeted optogenetic stimulation to moving C. elegans populations.PLoS biology · 2022Article
- Three-Dimensional Tracking of Multiple Small Insects by a Single Camera.Journal of insect science (Online) · 2021Article
- Controlling the behaviour of Drosophila melanogaster via smartphone optogenetics.Scientific reports · 2020Article
- Article
- Anti-instinctive Learning Behavior Revealed by Locomotion-Triggered Mild Heat Stress inFrontiers in behavioral neuroscience · 2020Article
- Random Walk Revisited: Quantification and Comparative Analysis of Drosophila Walking Trajectories.iScience · 2019Article
- Functional Imaging and Optogenetics inGenetics · 2018Review
- Long-term optical brain imaging in live adult fruit flies.Nature communications · 2018Article
- Anion-conducting channelrhodopsins with tuned spectra and modified kinetics engineered for optogenetic manipulation of behavior.Scientific reports · 2017Article
- Toward Whole-Body Connectomics.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Review
- Flyception: imaging brain activity in freely walking fruit flies.Nature methods · 2016Article
- Illuminating odors: when optogenetics brings to light unexpected olfactory abilities.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Review
- Non-invasive manipulation of Drosophila behavior by two-photon excited red-activatable channelrhodopsin.Biomedical optics express · 2015Article
- Three-wavelength light control of freely moving Drosophila Melanogaster for less perturbation and efficient social-behavioral studies.Biomedical optics express · 2015Article
- Control of Protein Activity and Cell Fate Specification via Light-Mediated Nuclear Translocation.PloS one · 2015Article
- Inner workings: Controlling flies with lasers.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
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Authors and funding
8 authors at 4 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present an automated laser tracking and optogenetic manipulation system (ALTOMS) for studying social memory in fruit flies (Drosophila melanogaster). ALTOMS comprises an intelligent central control module for high-speed fly behavior analysis and feedback laser scanning (∼40 frames per second) for targeting two lasers (a 473-nm blue laser and a 593.5-nm yellow laser) independently on any specified body parts of two freely moving Drosophila adults. By using ALTOMS to monitor and compute the locations, orientations, wing postures, and relative distance between two flies in real time and using high-intensity laser irradiation as an aversive stimulus, this laser tracking system can be used for an operant conditioning assay in which a courting male quickly learns and forms a long-lasting memory to stay away from a freely moving virgin female. With the equipped lasers, channelrhodopsin-2 and/or halorhodopsin expressed in selected neurons can be triggered on the basis of interactive behaviors between two flies. Given its capacity for optogenetic manipulation to transiently and independently activate/inactivate selective neurons, ALTOMS offers opportunities to systematically map brain circuits that orchestrate specific Drosophila behaviors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.