ArticleProceedings of the National Academy of Sciences of the United States of America2014
Regional brain responses associated with drinking water during thirst and after its satiation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Sugar-free chewing gum's effect on patients receiving maintenance hemodialysis: a meta-analysis of RCTs.BMC nephrology · 2025Pooled it
- The cerebellum plays more than one role in the dysregulation of appetite: Review of structural evidence from typical and eating disorder populations.Brain and behavior · 2023Pooled it
- Sequence of episodic memory-related behavioral and brain-imaging abnormalities in type 2 diabetes.Nutrition & diabetes · 2025Trial
- Menthol chewing gum on preoperative thirst management: randomized clinical trial.Revista latino-americana de enfermagem · 2019Trial
- Neural effects of cannabinoid CB1 neutral antagonist tetrahydrocannabivarin on food reward and aversion in healthy volunteers.The international journal of neuropsychopharmacology · 2014Trial
- Pathophysiology and treatment of exercise-associated hyponatremia.Journal of endocrinological investigation · 2026Review
- Autonomic and neurosensory disorders in dementia with lewy bodies: prevalence and neural basis in the AlphaLewyMA cohort.Alzheimer's research & therapy · 2025Article
- Perspectives on enhancing human performance in the heat: Is the solution to simply "just add water"?Sports medicine and health science · 2025Review
- Reference Values for Hydration Biomarkers: Optimizing Athletic Performance and Recovery.Open access journal of sports medicine · 2025Review
- The neurobiology of thirst and salt appetite.Neuron · 2024Review
- Review
- The cerebellum modulates thirst.Nature neuroscience · 2024Article
- The Interaction of Vasopressin with Hormones of the Hypothalamo-Pituitary-Adrenal Axis: The Significance for Therapeutic Strategies in Cardiovascular and Metabolic Diseases.International journal of molecular sciences · 2024Review
- Use of a menthol popsicle in managing postoperative thirst in patients undergoing radical prostatectomy: A randomized clinical trial.SAGE open medicine · 2023Article
- Dehydration and rehydration affect brain regional density and homogeneity among young male adults, determinedFrontiers in nutrition · 2022Article
- Rational regulation of water-seeking effort in rodents.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- A Subset of Primary Polydipsia, "Dipsogneic Diabetes Insipidus", in Apparently Healthy People Due to Excessive Water Intake: Not Enough Light to Illuminate the Dark Tunnel.Healthcare (Basel, Switzerland) · 2021Review
- Psychogenic polydipsia in a female adolescent without a psychiatric background: A case report.Clinical case reports · 2021Article
- Regional brain responses associated with using imagination to evoke and satiate thirst.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The instinct of thirst was a cardinal element in the successful colonization by vertebrates of the dry land of the planet, which began in the Ordovician period about 400 million y ago. It is a commonplace experience in humans that drinking water in response to thirst following fluid loss is a pleasant experience. However, continuing to drink water once thirst has been satiated becomes unpleasant and, eventually, quite aversive. Functional MRI experiments reported here show pleasantness of drinking is associated with activation in the anterior cingulate cortex (Brodmann area 32) and the orbitofrontal cortex. The unpleasantness and aversion of overdrinking is associated with activation in the midcingulate cortex, insula, amygdala, and periaqueductal gray. Drinking activations in the putamen and cerebellum also correlated with the unpleasantness of water, and the motor cortex showed increased activation during overdrinking compared with drinking during thirst. These activations in motor regions may possibly reflect volitional effort to conduct compliant drinking in the face of regulatory mechanisms inhibiting intake. The results suggestive of a specific inhibitory system in the control of drinking are unique.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.