ArticleProceedings of the National Academy of Sciences of the United States of America2014
Cellular mechanisms for integral feedback in visually guided behavior.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 71 citations in OpenAlex.
- Article
- How tp1, an indirect wing steering muscle, stabilizesbioRxiv : the preprint server for biology · 2025Article
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- Neuromuscular embodiment of feedback control elements inScience advances · 2022Article
- Multiple mechanisms mediate the suppression of motion vision during escape maneuvers in flyingiScience · 2022Article
- Walking strides direct rapid and flexible recruitment of visual circuits for course control in Drosophila.Neuron · 2022Article
- The impulse response of optic flow-sensitive descending neurons to roll m-sequences.The Journal of experimental biology · 2021Article
- Fast tuning of posture control by visual feedback underlies gaze stabilization in walking Drosophila.Current biology : CB · 2021Article
- Article
- Object features and T4/T5 motion detectors modulate the dynamics of bar tracking byThe Journal of experimental biology · 2019Article
- Behavioral state modulates the ON visual motion pathway ofProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Eyes Matched to the Prize: The State of Matched Filters in Insect Visual Circuits.Frontiers in neural circuits · 2018Review
- Sensation during Active Behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Review
- Drosophila Spatiotemporally Integrates Visual Signals to Control Saccades.Current biology : CB · 2017Article
- Parallel encoding of recent visual experience and self-motion during navigation in Drosophila.Nature neuroscience · 2017Article
- A Descending Neuron Correlated with the Rapid Steering Maneuvers of Flying Drosophila.Current biology : CB · 2017Article
- Descending Neurons inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Flies compensate for unilateral wing damage through modular adjustments of wing and body kinematics.Interface focus · 2017Article
- Article
- A faithful internal representation of walking movements in the Drosophila visual system.Nature neuroscience · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sensory feedback is a ubiquitous feature of guidance systems in both animals and engineered vehicles. For example, a common strategy for moving along a straight path is to turn such that the measured rate of rotation is zero. This task can be accomplished by using a feedback signal that is proportional to the instantaneous value of the measured sensory signal. In such a system, the addition of an integral term depending on past values of the sensory input is needed to eliminate steady-state error [proportional-integral (PI) control]. However, the means by which nervous systems implement such a computation are poorly understood. Here, we show that the optomotor responses of flying Drosophila follow a time course consistent with temporal integration of horizontal motion input. To investigate the cellular basis of this effect, we performed whole-cell patch-clamp recordings from the set of identified visual interneurons [horizontal system (HS) cells] thought to control this reflex during tethered flight. At high stimulus speeds, HS cells exhibit steady-state responses during flight that are absent during quiescence, a state-dependent difference in physiology that is explained by changes in their presynaptic inputs. However, even during flight, the membrane potential of the large-field interneurons exhibits no evidence for integration that could explain the behavioral responses. However, using a genetically encoded indicator, we found that calcium accumulates in the terminals of the interneurons along a time course consistent with the behavior and propose that this accumulation provides a mechanism for temporal integration of sensory feedback consistent with PI control.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.