ArticleThe Journal of biological chemistry2014
Cell penetrating peptides and cationic antibacterial peptides: two sides of the same coin.
Article in The Journal of biological chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Membrane-Active Peptides and Their Potential Biomedical Application.Pharmaceutics · 2023Review
- Bypassing the Need for Cell Permeabilization: Nanobody CDR3 Peptide Improves Binding on Living Bacteria.Bioconjugate chemistry · 2023Article
- Antimicrobial peptides as drugs with double response againstFrontiers in microbiology · 2023Review
- Peptides as Pharmacological Carriers to the Brain: Promises, Shortcomings and Challenges.Molecular pharmaceutics · 2022Review
- Antimicrobial peptides with cell-penetrating activity as prophylactic and treatment drugs.Bioscience reports · 2022Review
- αA and αB peptides from human cataractous lenses show antichaperone activity and enhance aggregation of lens proteins.Molecular vision · 2022Article
- Selective Moonlighting Cell-Penetrating Peptides.Pharmaceutics · 2021Article
- Uncoupling the Folding-Function Paradigm of Lytic Peptides to Deliver Impermeable Inhibitors of Intracellular Protein-Protein Interactions.Journal of the American Chemical Society · 2020Article
- Antimicrobial Peptide againstPharmaceutics · 2020Article
- Designing Chimeric Molecules for Drug Discovery by Leveraging Chemical Biology.Journal of medicinal chemistry · 2020Review
- Whole-Genome Approach to Understanding the Mechanism of Action of a Histatin 5-Derived Peptide.Antimicrobial agents and chemotherapy · 2020Article
- The effect of turn residues on the folding and cell-penetrating activity of β-hairpin peptides and applications toward protein delivery.Peptide science (Hoboken, N.J.) · 2020Article
- Antitumor and antibacterial properties of virally encoded cationic sequences.Biologics : targets & therapy · 2019Article
- Membrane Active Peptides and Their Biophysical Characterization.Biomolecules · 2018Review
- An Antimicrobial Peptide InducesFrontiers in microbiology · 2018Article
- Prediction of Cell-Penetrating Potential of Modified Peptides Containing Natural and Chemically Modified Residues.Frontiers in microbiology · 2018Article
- Mapping and Identification of Antifungal Peptides in the Putative Antifungal Protein AfpB from the Filamentous FungusFrontiers in microbiology · 2017Article
- Protein-stabilizing and cell-penetrating properties of α-helix domain of 30Kc19 protein.Biotechnology journal · 2016Article
- Effective Design of Multifunctional Peptides by Combining Compatible Functions.PLoS computational biology · 2016Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell penetrating peptides (CPP) and cationic antibacterial peptides (CAP) have similar physicochemical properties and yet it is not understood how such similar peptides display different activities. To address this question, we used Iztli peptide 1 (IP-1) because it has both CPP and CAP activities. Combining experimental and computational modeling of the internalization of IP-1, we show it is not internalized by receptor-mediated endocytosis, yet it permeates into many different cell types, including fungi and human cells. We also show that IP-1 makes pores in the presence of high electrical potential at the membrane, such as those found in bacteria and mitochondria. These results provide the basis to understand the functional redundancy of CPPs and CAPs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.