ArticleHuman genetics1989
Two type II keratin genes are localized on human chromosome 12.
Article in Human genetics, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 48 citations in OpenAlex.
- Epidermolytic hyperkeratosis: clinical update.Clinical, cosmetic and investigational dermatology · 2019Review
- Keratin expression in breast cancers.Virchows Archiv : an international journal of pathology · 2012Article
- Comparative genomics of the keratin-associated protein (KAP) gene clusters in human, chimpanzee, and baboon.Mammalian genome : official journal of the International Mammalian Genome Society · 2004Article
- Close linkage of retinoic acid receptor genes with homeobox- and keratin-encoding genes on paralogous segments of mouse chromosomes 11 and 15.Mammalian genome : official journal of the International Mammalian Genome Society · 1992Article
- Mapping of epidermolysis bullosa simplex mutation to chromosome 12.American journal of human genetics · 1991Article
- Localisation of a cDNA clone for human cytokeratin 18 to chromosome 17p11-p12 by in situ hybridisation.Human genetics · 1990Article
- Allele frequencies and segregation of human polymorphic keratins K4 and K5.American journal of human genetics · 1990Article
- Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors.Proceedings of the National Academy of Sciences of the United States of America · 1989Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human genomic DNA containing two type II keratin genes, one coding for keratin 1 (K1, a 68-kD basic protein) and another closely linked type II gene 10-15 kb upstream (K?, gene product unknown), was isolated on a single cosmid clone. EcoRI restriction fragments of the cosmid were subcloned into pGEM-3Z, and specific probes comprising the C-terminal coding and 3' noncoding regions of the two genes were constructed. The type II keratin genes were localized by in situ hybridization of the subcloned probes to normal human lymphocyte chromosomes. In a total of 70 chromosome spreads hybridized with the K? probe (gHK?-3', PstI, 800 bp), 36 of the 105 grains observed were on chromosome 12, and 32 of these were clustered on the long arm near the centromere (12q11-13). In 100 labeled metaphases hybridized with the K1 probe (gHK1-3', BamHI-PstI, 2100 bp), 53 grains localized to chromosome 12 and 46 of these were found in the same region (q11-13). Therefore, both the gene for human keratin 1, a specific marker for terminal differentiation in mammalian epidermis, and another closely linked unknown type II keratin gene (K?, 10-15 kb upstream of K1) are on the long arm (q11-13) of human chromosome 12.
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