ArticleAngewandte Chemie (International ed. in English)2014
Design of monodisperse and well-defined polypeptide-based polyvalent inhibitors of anthrax toxin.
Article in Angewandte Chemie (International ed. in English), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Dendrimeric Antigens for Passive Mast Cell Activation in the Evaluation of Amoxicillin Allergy.Allergy · 2026Article
- Discovery of Stable and Selective Antibody Mimetics from Combinatorial Libraries of Polyvalent, Loop-Functionalized Peptoid Nanosheets.ACS nano · 2020Article
- Fabrication of rigidity and space variable protein oligomers with two peptide linkers.Chemical science · 2019Article
- Nanostructured glycan architecture is important in the inhibition of influenza A virus infection.Nature nanotechnology · 2017Article
- Recent advances in engineering polyvalent biological interactions.Biomacromolecules · 2015Review
- Multivalent Inhibitors of Channel-Forming Bacterial Toxins.Current topics in microbiology and immunologyReview
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
The design of polyvalent molecules, presenting multiple copies of a specific ligand, represents a promising strategy to inhibit pathogens and toxins. The ability to control independently the valency and the spacing between ligands would be valuable for elucidating structure-activity relationships and for designing potent polyvalent molecules. To that end, we designed monodisperse polypeptide-based polyvalent inhibitors of anthrax toxin in which multiple copies of an inhibitory toxin-binding peptide were separated by flexible peptide linkers. By tuning the valency and linker length, we designed polyvalent inhibitors that were over four orders of magnitude more potent than the corresponding monovalent ligands. This strategy for the rational design of monodisperse polyvalent molecules may not only be broadly applicable for the inhibition of toxins and pathogens, but also for controlling the nanoscale organization of cellular receptors to regulate signaling and the fate of stem cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.