ArticlePlant physiology2014
The Polyadenylation Factor Subunit CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR30: A Key Factor of Programmed Cell Death and a Regulator of Immunity in Arabidopsis.
Article in Plant physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 64 citations in OpenAlex.
- A pan-genomic perspective: comprehensive dissection of the FIG superfamily unravels its evolution, expansion, and environmental adaptation in wheat.BMC plant biology · 2026Article
- Alternative Polyadenylation Dynamics During the Rice Blast Immune Response.Molecular plant pathology · 2026Article
- The role of NTAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Review
- Insights into the role of N6-methyladenosine (m6A) in plant-virus interactions.Journal of virology · 2025Review
- Early changes in microRNA expression in Arabidopsis plants infected with the fungal pathogen Fusarium graminearum.PloS one · 2025Article
- Article
- Characterizing the impact of CPSF30 gene disruption on TuMV infection inGM crops & food · 2024Article
- Early changes in microRNA expression in Arabidopsis plants infected with the fungal pathogenbioRxiv : the preprint server for biology · 2024Article
- Stress responses of plants through transcriptome plasticity by mRNA alternative polyadenylation.Molecular horticulture · 2023Review
- A LlMYB305-LlC3H18-LlWRKY33 module regulates thermotolerance in lily.Molecular horticulture · 2023Article
- Alternative Polyadenylation Is a Novel Strategy for the Regulation of Gene Expression in Response to Stresses in Plants.International journal of molecular sciences · 2023Review
- Natural variation in the plant polyadenylation complex.Frontiers in plant science · 2023Article
- Transcriptome-wide m6A methylation in natural yellow leaf ofFrontiers in plant science · 2023Article
- Epitranscriptomic mRNA modifications governing plant stress responses: underlying mechanism and potential application.Plant biotechnology journal · 2022Review
- Hormone Regulation of CCCH Zinc Finger Proteins in Plants.International journal of molecular sciences · 2022Review
- Transitions of foliar mycobiota community and transcriptome in response to pathogenic conifer needle interactions.Scientific reports · 2022Article
- CONSTITUTIVE EXPRESSER OF PATHOGENESIS-RELATED GENES 5 is an RNA-binding protein controlling plant immunity via an RNA processing complex.The Plant cell · 2022Article
- Signatures of mRNA Alternative Polyadenylation inFrontiers in genetics · 2022Article
- Inositol Improves Cold Tolerance Through InhibitingFrontiers in plant science · 2022Article
- Transcriptome-wide N6-methyladenosine (mBMC plant biology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Programmed cell death (PCD) is essential for several aspects of plant life, including development and stress responses. Indeed, incompatible plant-pathogen interactions are well known to induce the hypersensitive response, a localized cell death. Mutational analyses have identified several key PCD components, and we recently identified the mips1 mutant of Arabidopsis (Arabidopsis thaliana), which is deficient for the key enzyme catalyzing the limiting step of myoinositol synthesis. One of the most striking features of mips1 is the light-dependent formation of lesions on leaves due to salicylic acid (SA)-dependent PCD, revealing roles for myoinositol or inositol derivatives in the regulation of PCD. Here, we identified a regulator of plant PCD by screening for mutants that display transcriptomic profiles opposing that of the mips1 mutant. Our screen identified the oxt6 mutant, which has been described previously as being tolerant to oxidative stress. In the oxt6 mutant, a transfer DNA is inserted in the CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR30 (CPSF30) gene, which encodes a polyadenylation factor subunit homolog. We show that CPSF30 is required for lesion formation in mips1 via SA-dependent signaling, that the prodeath function of CPSF30 is not mediated by changes in the glutathione status, and that CPSF30 activity is required for Pseudomonas syringae resistance. We also show that the oxt6 mutation suppresses cell death in other lesion-mimic mutants, including lesion-simulating disease1, mitogen-activated protein kinase4, constitutive expressor of pathogenesis-related genes5, and catalase2, suggesting that CPSF30 and, thus, the control of messenger RNA 3' end processing, through the regulation of SA production, is a key component of plant immune responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.