ArticleInternational journal of cancer2014
Dietary intake of fish, ω-3 and ω-6 fatty acids and risk of colorectal cancer: A prospective study in U.S. men and women.
Article in International journal of cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 7 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
56 citing papers in PubMed, 7 syntheses or guidelines pooled it, 97 citations in OpenAlex.
- Inverse association between eicosapentaenoic acid and incident colorectal cancer: a dose-response meta-analysis of twenty-six independent prospective cohorts.European journal of nutrition · 2025Pooled it
- Dietary intake and tissue biomarkers of omega-6 fatty acids and risk of colorectal cancer in adults: a systematic review and dose-response meta-analysis of prospective cohort studies.Nutrition & diabetes · 2025Pooled it
- Comprehensive Investigation on Associations between Dietary Intake and Blood Levels of Fatty Acids and Colorectal Cancer Risk.Nutrients · 2023Pooled it
- Dietary fatty acids and colorectal cancer risk in men: A report from the Shanghai Men's Health Study and a meta-analysis.International journal of cancer · 2021Pooled it
- N-6 Polyunsaturated Fatty Acids and Risk of Cancer: Accumulating Evidence from Prospective Studies.Nutrients · 2020Pooled it
- Dietary Fat Intake and Risk of Colorectal Cancer: A Systematic Review and Meta-Analysis of Prospective Studies.Nutrients · 2018Pooled it
- Biospecimen long-chain N-3 PUFA and risk of colorectal cancer: a meta-analysis of data from 60,627 individuals.PloS one · 2014Pooled it
- The role of gut microbiota and its metabolites in preventing oncogenesis.Frontiers in cell and developmental biology · 2026Review
- Fish Intake and Polyunsaturated Fatty Acids in Relation to Colorectal Cancer Risk in the Black Women's Health Study.The Journal of nutrition · 2025Article
- Associations of plasma omega-6 and omega-3 fatty acids with overall and 19 site-specific cancers: A population-based cohort study in UK Biobank.International journal of cancer · 2025Article
- Fish oil supplement use modifies the relationship between dietary oily fish intake and plasmaThe British journal of nutrition · 2024Article
- Associations of plasma omega-6 and omega-3 fatty acids with overall and 19 site-specific cancers: a population-based cohort study in UK Biobank.medRxiv : the preprint server for health sciences · 2024Article
- Review
- Impact of Diet on Colorectal Cancer Progression and Prevention: From Nutrients to Neoplasms.The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2023Review
- Association between dietary intake of n-3 polyunsaturated fatty acids and risk of colorectal cancer in the Japanese population: The Japan Collaborative Cohort Study.Cancer medicine · 2023Article
- Association between Dietary Fatty Acid Patterns and Colorectal Cancer Risk: A Large-Scale Case-Control Study in China.Nutrients · 2022Article
- Dietary Intervention for Preventing Colorectal Cancer: A Practical Guide for Physicians.Journal of cancer prevention · 2022Review
- Dereplication of Cytochalasans and Octaketides in Cytotoxic Extracts of Endophytic Fungi fromMetabolites · 2022Article
- On optimal two-stage testing of multiple mediators.Biometrical journal. Biometrische Zeitschrift · 2022Article
- Inverse Association between Canned Fish Consumption and Colorectal Cancer Risk: Analysis of Two Large Case-Control Studies.Nutrients · 2022Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
The association between fish, ω-3 and ω-6 polyunsaturated fatty acid (PUFA) intake and risk of colorectal cancer (CRC) remains inconclusive. Recent prospective studies suggest that the relationship may vary by gender, subsite and duration of follow-up. We followed 123,529 US adults (76,386 women and 47,143 men) without a history of cancer at baseline for 24 to 26 years. Fish and PUFA intake was assessed at baseline and updated every 4 years by using a validated food-frequency questionnaire. We found no overall association between fish, ω-3 and ω-6 PUFA intake and CRC risk with hazard ratio (HR) of 1.03 [95% confidence interval (CI): 0.89-1.20] comparing marine ω-3 intake of ≥ 0.30 g/d versus <0.15 g/d among women and 1.05 (95% CI: 0.85-1.30) comparing intake of ≥ 0.41 g/d versus <0.16 g/d among men. However, fish and marine ω-3 PUFA intake appeared to be positively associated with risk of distal colon cancer in both men and women and inversely with risk of rectal cancer in men. In an analysis based on a limited number of cases, marine ω-3 PUFA intake assessed 12-16 years before diagnosis tended to be inversely associated with CRC risk in men (HR: 0.76; 95% CI: 0.52-1.10). In conclusion, although no overall association between fish, ω-3 or ω-6 PUFA intake was observed with CRC risk, marine ω-3 PUFA may be differentially associated with risk of distal colon and rectal cancers and a long latency may be needed for its protection against CRC in men.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.