ArticleJournal of bioenergetics and biomembranes2014
An exploration of how the thermodynamic efficiency of bioenergetic membrane systems varies with c-subunit stoichiometry of F₁F₀ ATP synthases.
Article in Journal of bioenergetics and biomembranes, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 53 citations in OpenAlex.
- The molecular mechanism of ATP synthase constrains the evolutionary landscape of chemiosmosis.Biophysical journal · 2025Review
- Oxidative Phosphorylation Does Not Violate the Second Law of Thermodynamics.The journal of physical chemistry. B · 2024Article
- Review
- Modeling control and transduction of electrochemical gradients in acid-stressed bacteria.iScience · 2023Article
- Serpentinization as the source of energy, electrons, organics, catalysts, nutrients and pH gradients for the origin of LUCA and life.Frontiers in microbiology · 2023Review
- A critique of the capacitor-based "Transmembrane Electrostatically Localized Proton" hypothesis.Journal of bioenergetics and biomembranes · 2022Review
- Mitochondrial energetics with transmembrane electrostatically localized protons: do we have a thermotrophic feature?Scientific reports · 2021Article
- Energy Renewal: Isothermal Utilization of Environmental Heat Energy with Asymmetric Structures.Entropy (Basel, Switzerland) · 2021Article
- Rotor subunits adaptations in ATP synthases from photosynthetic organisms.Biochemical Society transactions · 2021Review
- Graphene Quantum Dots as Intracellular Imaging-Based Temperature Sensors.Materials (Basel, Switzerland) · 2021Article
- The Proton in Biochemistry: Impacts on Bioenergetics, Biophysical Chemistry, and Bioorganic Chemistry.Frontiers in molecular biosciences · 2021Review
- Amino Acid and Sugar Catabolism in the Marine Bacterium Phaeobacter inhibens DSM 17395 from an Energetic Viewpoint.Applied and environmental microbiology · 2019Article
- Electrostatically localized proton bioenergetics: better understanding membrane potential.Heliyon · 2019Article
- Mechanisms for achieving high speed and efficiency in biomolecular machines.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Optimization of ATP Synthase c-Rings for Oxygenic Photosynthesis.Frontiers in plant science · 2019Article
- Article
- Limitations to photosynthesis by proton motive force-induced photosystem II photodamage.eLife · 2016Article
- Biophysical comparison of ATP synthesis mechanisms shows a kinetic advantage for the rotary process.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- The c-Ring of the F1FO-ATP Synthase: Facts and Perspectives.The Journal of membrane biology · 2016Review
- Thermodynamics and kinetics of the FoF1-ATPase: application of the probability isotherm.Royal Society open science · 2016Article
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1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently the F0 portion of the bovine mitochondrial F1F0-ATP synthase was shown to contain eight 'c' subunits (n = 8). This surprised many in the field, as previously, the only other mitochondrial F0 (for yeast) was shown to have ten 'c' subunits. The metabolic implications of 'c' subunit copy number explored in this paper lead to several surprising conclusions: (1) Aerobically respiring E. coli (n = 10) and animal mitochondria (n = 8) both have very high F1F0 thermodynamic efficiencies of ≈90% under typical conditions, whereas efficiency is only ≈65% for chloroplasts (n = 14). Reasons for this difference, including the importance of transmembrane potential (∆Ψ) as a rotational catalyst, as opposed to an energy source, are discussed. (2) Maximum theoretical P/O ratios in animal mitochondria (n = 8) are calculated to be 2.73 ATP/NADH and 1.64 ATP/FADH2, yielding 34.5 ATP/glucose (assuming NADH import via the malate/aspartate shuttle). The experimentally measured values of 2.44 (±0.15), 1.47 (±0.13), and 31.3 (±1.5), respectively, are only about 10% lower, suggesting very little energy depletion via transmembrane proton leakage. (3) Finally, the thermodynamic efficiency of oxidative phosphorylation is not lower than that of substrate level phosphorylation, as previously believed. The overall thermodynamic efficiencies of oxidative phosphorylation, glycolysis, and the citric acid cycle are ≈80% in all three processes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.