ArticleClinical autonomic research : official journal of the Clinical Autonomic Research Society2014
Quantitative indices of baroreflex-sympathoneural function: application to patients with chronic autonomic failure.
Article in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
- Distinct Sympathoneural and Cardiovagal Domains of Arterial Baroreflex Function in Autonomic Synucleinopathies.Research square · 2026Article
- Hemodynamics, plasma catecholamines, and power spectral analysis of heart rate variability during tilt-evoked neurally mediated hypotension.Frontiers in neuroscience · 2026Article
- "Body-first" dementia with Lewy bodies.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- Tilt-evoked, breathing-driven blood pressure oscillations: Independence from baroreflex-sympathoneural function.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024Observational
- Cardiac noradrenergic deficiency revealed by 18F-dopamine positron emission tomography identifies preclinical central Lewy body diseases.The Journal of clinical investigation · 2024Article
- Deep Phenotyping of Neurologic Postacute Sequelae of SARS-CoV-2 Infection.Neurology(R) neuroimmunology & neuroinflammation · 2023Observational
- Baroreflex-sympathoneural dysfunction characterizes at-risk individuals with preclinical central Lewy body diseases.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023Article
- The Pathogenesis and Treatment of Cardiovascular Autonomic Dysfunction in Parkinson's Disease: What We Know and Where to Go.Aging and disease · 2021Review
- Do indices of baroreflex failure and peripheral noradrenergic deficiency predict the magnitude of orthostatic hypotension in Lewy body diseases?Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021Article
- Beat-to-beat blood pressure and heart rate responses to the Valsalva maneuver.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2017Review
- Parkinson's disease between internal medicine and neurology.Journal of neural transmission (Vienna, Austria : 1996) · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
purposeChronic autonomic failure syndromes such as Parkinson disease with orthostatic hypotension (PD + OH), multiple system atrophy (MSA), and pure autonomic failure (PAF) typically feature arterial baroreflex failure. Identifying baroreflex-sympathoneural failure from hemodynamic responses to the maneuver usually has been qualitative. We report quantitative methods for evaluating baroreflex-sympathoneural function, based on beat-to-beat systolic blood pressure (BPs) responses to the Valsalva maneuver.
methodUsing the trapezoid rule, we calculated the area under the curve (baroreflex area, BRA) between baseline systolic blood pressure (BPs) and the BPs for each beat in Phase II (BRA-II) and Phase IV (BRA-IV) in 136 autonomic failure patients and 171 controls. The sum of the areas was defined as total BRA (BRA-T). We compared individual values by the BRA approach with those by other measures.
resultsMean values for log BRA-II, BRA-IV, and BRA-T were higher in PD + OH, PAF, and MSA than in controls (p < 0.001 each). The log of BRA-T correlated negatively with the fractional orthostatic change in total peripheral resistance (r = -0.41, p < 0.001), fractional orthostatic change in plasma norepinephrine (r = -0.27, p < 0.001), orthostatic change in BPs (r = -0.62, p < 0.001), fall in BPs in Phase II of the Valsalva (r = 0.58, p < 0.001), and log of baroreflex-cardiovagal slope (r = -0.40, p < 0.001). Areas under receiver operating characteristic curves were 0.85 for BRA-T and 0.89 for BRA-IV (p < 0.001).
conclusionThe BRA approach provides quantitative measures of baroreflex-sympathoneural function. Chronic autonomic failure syndromes entail deficiencies of both the cardiovagal and sympathoneural limbs of the arterial baroreflex.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.