SynthesisJournal of gastrointestinal cancer2014
Meta-analysis of the association between PTPN11 G/A polymorphism at intron 3 with risk of gastric atrophy among East Asians.
Synthesis in Journal of gastrointestinal cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
0 citing papers in PubMed, 9 citations in OpenAlex.
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Authors and funding
4 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimInconsistency of reported associations of the G/A polymorphism (rs2301756) in the PTPN11 gene and gastric atrophy prompted us to undertake a meta-analysis. MATERIALS AND
methodsWe searched PubMed for published literature up to July 2013. Individual data from studies with case-control design were evaluated for the PTPN11 G/A polymorphism in Helicobacter pylori (-) (seronegative) and (+) (seropositive) subjects (four studies each, totaling 3,597 cases and 4,865 controls).
resultsAssociations of PTPN11 polymorphism with gastric atrophy in H. pylori (-) and (+) subjects are more readily interpreted in the homozygous and recessive models given that the dominant codominant effects skirted null associations. Thus, homozygous and recessive effects indicated reduced risk [odds ratio (OR) 0.92-0.96, p = 0.51-0.74], which is significant among H. pylori (+) subjects (OR 0.66-0.68, p = 0.04-0.05). Confined to the Japanese, reduced risk effects were unaltered in both groups, less protective among seronegative subjects (OR 0.85-0.86, p = 0.71-0.73) than seropositive subjects with significance in the recessive model (OR 0.67, p = 0.05). Sensitivity analysis demonstrated robustness of the seropositive findings, but probably not the seronegative results where homozygous and recessive pooled ORs were altered from protection to increased risk.
conclusionsEvidence of overall and subgroup decreased risks, strong in seropositive subjects, demonstrates protective effects of the PTPN11 G/A polymorphism from gastric atrophy.
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