Evidence map›Paper›PMID 24706080›Full record

ArticleBehavior research methods2015

SCORHE: a novel and practical approach to video monitoring of laboratory mice housed in vivarium cage racks.

Ghadi H Salem, John U Dennis, Jonathan Krynitsky, Marcial Garmendia-Cedillos, Kanchan Swaroop, James D Malley, Sinisa Pajevic, Liron Abuhatzira, Michael Bustin, Jean-Pierre Gillet and 3 more

Abstract read
In one paragraph

Article in Behavior research methods, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
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  6. Review
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  11. Article
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  13. Three-Dimensional Pose Estimation for Laboratory Mouse From Monocular Images.IEEE transactions on image processing : a publication of the IEEE Signal Processing Society · 2019
    Article
  14. Effects of High-Fat Diet and Body Mass on Bone Morphology and Mechanical Properties in 1100 Advanced Intercross Mice.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2019
    Article
  15. Recommended housing densities for research mice: filling the gap in data-driven alternatives.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019
    Review
  16. Article
  17. Article
  18. Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ghadi H SalemDivision of Computational Bioscience, Center for Information Technology, National Institutes of Health, 12 South Drive, Building 12A Room 2025, Bethesda, MD, 20892, USA, salem@exchange.nih.gov.
John U Dennis
Jonathan Krynitsky
Marcial Garmendia-Cedillos
Kanchan Swaroop
James D Malley
Sinisa Pajevic
Liron Abuhatzira
Michael Bustin
Jean-Pierre Gillet
Michael M Gottesman
James B Mitchell
Thomas J Pohida

Funding

Signal Processing And Instrumentation SectionZIACT000261 · CIT · CENTER FOR INFORMATION TECHNOLOGY · PI POHIDA, THOMAS J · 2009 to 2021
$16.7M
Biological Functions of Chromosomal ProteinsZIABC011154 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI BUSTIN, MICHAEL · 2009 to 2023
$11.0M
White Matter Connectivity and Network AnalysisZIACT000275 · CIT · CENTER FOR INFORMATION TECHNOLOGY · PI PAJEVIC, SINISA · 2013 to 2020
$1.8M
Statistical Learning for Biomedical DataZIACT000271 · CIT · CENTER FOR INFORMATION TECHNOLOGY · PI MALLEY, JAMES D · 2009 to 2017
$1.2M
Intramural NIH HHS Z99 CT999999
6 · The paper itself

Abstract

The System for Continuous Observation of Rodents in Home-cage Environment (SCORHE) was developed to demonstrate the viability of compact and scalable designs for quantifying activity levels and behavior patterns for mice housed within a commercial ventilated cage rack. The SCORHE in-rack design provides day- and night-time monitoring with the consistency and convenience of the home-cage environment. The dual-video camera custom hardware design makes efficient use of space, does not require home-cage modification, and is animal-facility user-friendly. Given the system's low cost and suitability for use in existing vivariums without modification to the animal husbandry procedures or housing setup, SCORHE opens up the potential for the wider use of automated video monitoring in animal facilities. SCORHE's potential uses include day-to-day health monitoring, as well as advanced behavioral screening and ethology experiments, ranging from the assessment of the short- and long-term effects of experimental cancer treatments to the evaluation of mouse models. When used for phenotyping and animal model studies, SCORHE aims to eliminate the concerns often associated with many mouse-monitoring methods, such as circadian rhythm disruption, acclimation periods, lack of night-time measurements, and short monitoring periods. Custom software integrates two video streams to extract several mouse activity and behavior measures. Studies comparing the activity levels of ABCB5 knockout and HMGN1 overexpresser mice with their respective C57BL parental strains demonstrate SCORHE's efficacy in characterizing the activity profiles for singly- and doubly-housed mice. Another study was conducted to demonstrate the ability of SCORHE to detect a change in activity resulting from administering a sedative.

Indexed as

Housing, AnimalAdaptation, PsychologicalAnimalsBehavior, AnimalCircadian RhythmComputer-Aided DesignHypnotics and SedativesMiceMice, Inbred C57BLModels, AnimalVideo RecordingHypnotics and Sedatives

Identifiers

PMID24706080
PMCPMC4570574

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.