ArticleNeurochemical research2014
A site-specific phosphorylation of the focal adhesion kinase controls the formation of spheroid cell clusters.
Article in Neurochemical research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Mesenchymal Stromal Cell-Produced Components of Extracellular Matrix Potentiate Multipotent Stem Cell Response to Differentiation Stimuli.Frontiers in cell and developmental biology · 2020Article
- E-cadherin, actin, microtubules and FAK dominate different spheroid formation phases and important elements of tissue integrity.Biology open · 2019Article
- Article
- The hedgehog-signaling pathway is repressed during the osteogenic differentiation of dental follicle cells.Molecular and cellular biochemistry · 2017Article
- Evaluation of implant-materials as cell carriers for dental stem cells under in vitro conditions.International journal of implant dentistry · 2015Article
- FAK activity protects nucleostemin in facilitating breast cancer spheroid and tumor growth.Breast cancer research : BCR · 2015Article
- The Urine Proteome Profile Is Different in Neuromyelitis Optica Compared to Multiple Sclerosis: A Clinical Proteome Study.PloS one · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human dental follicle cells (DFCs) are ectomesenchymal multipotent stem cells that form spheroid cell clusters (SCCs) under serum free medium cell culture conditions (SFM). Until today, molecular mechanisms for the formation of SCCs are unknown. In this study a quantitative phosphoproteomics approach revealed regulated phosphorylated proteins in SCCs, which were derived from DFCs after 24 and 48 h in SFM. These regulated proteins were categorized using the Kyoto encyclopedia of genes and genomes program. Here, cellular processes and signaling pathway were identified such as the focal adhesion kinase (FAK) signaling pathway. In addition to the phosphoproteomics approach we showed that a specific phosphorylation of FAK (Y397) was required for the formation of SCCs. In conclusion, this study disclosed the phosphoproteome of SCCs for the first time and showed that the FAK signaling pathway is required for the formation of SCCs.
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Registered trials
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