ReviewPflugers Archiv : European journal of physiology2014
Purinergic neuron-glia interactions in sensory systems.
Review in Pflugers Archiv : European journal of physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 45 citations in OpenAlex.
- Crosstalk of noradrenergic CaCell communication and signaling : CCS · 2026Article
- Early and Late Phases of Sensory-Evoked Olfactory Bulb Inhibition Are Mediated by Parallel Local Circuits: Attenuation of Fast Tufted Cell Axo-dendritic Inputs to Granule Cells by Adenosine A1 Receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- ATP Metabolism of Astrocytes: Consumption, Regeneration and Restoration.Neurochemical research · 2025Review
- Astrocytic activation increases blood flow in the adult olfactory bulb.Molecular brain · 2024Article
- AFrontiers in immunology · 2023Article
- Norepinephrine-Induced Calcium Signaling and Store-Operated Calcium Entry in Olfactory Bulb Astrocytes.Frontiers in cellular neuroscience · 2021Article
- Parallel astrocyte calcium signaling modulates olfactory bulb responses.Journal of neuroscience research · 2020Article
- The SNP rs2298383 Reduces ADORA2A Gene Transcription and Positively Associates with Cytokine Production by Peripheral Blood Mononuclear Cells in Patients with Multiple Chemical Sensitivity.International journal of molecular sciences · 2020Article
- A Circadian Clock in the Retina Regulates Rod-Cone Gap Junction Coupling and Neuronal Light ResponsesFrontiers in cellular neuroscience · 2020Article
- Age-Dependent Heterogeneity of Murine Olfactory Bulb Astrocytes.Frontiers in aging neuroscience · 2020Article
- Intrathecal injection of bone marrow stromal cells attenuates neuropathic pain via inhibition of P2XJournal of neuroinflammation · 2019Article
- AMPA Receptor-Mediated CaFrontiers in cellular neuroscience · 2019Article
- Purinergic Signaling in the Vertebrate Olfactory System.Frontiers in cellular neuroscience · 2019Review
- Adenosine AThe Journal of physiology · 2018Article
- Andrographolide Inhibits Mechanical and Thermal Hyperalgesia in a Rat Model of HIV-Induced Neuropathic Pain.Frontiers in pharmacology · 2018Article
- Common olfactory ensheathing glial markers in the developing human olfactory system.Brain structure & function · 2017Article
- CaScientific reports · 2017Article
- Adenosine AFrontiers in cellular neuroscience · 2017Article
- Sterile Neuroinflammation and Strategies for Therapeutic Intervention.International journal of inflammation · 2017Review
- Astroglial Connexin 43 Hemichannels Modulate Olfactory Bulb Slow Oscillations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purine adenosine 5'-triphosphate (ATP) and its breakdown products, ADP and adenosine, act as intercellular messenger molecules throughout the nervous system. While ATP contributes to fast synaptic transmission via activation of ionotropic P2X receptors as well as neuromodulation via metabotropic P2Y receptors, ADP and adenosine only stimulate P2Y and P1 receptors, respectively, thereby adjusting neuronal performance. Often glial cells are recipient as well as source for extracellular ATP. Hence, purinergic neuron-glia signalling contributes bidirectionally to information processing in the nervous system, including sensory organs and brain areas computing sensory information. In this review, we summarize recent data of purinergic neuron-glia communication in two sensory systems, the visual and the olfactory systems. In both retina and olfactory bulb, ATP is released by neurons and evokes Ca(2+) transients in glial cells, viz. Müller cells, astrocytes and olfactory ensheathing cells. Glial Ca(2+) signalling, in turn, affects homeostasis of the nervous tissue such as volume regulation and control of blood flow. In addition, 'gliotransmitter' release upon Ca(2+) signalling--evoked by purinoceptor activation--modulates neuronal activity, thus contributing to the processing of sensory information.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.