ArticleToxicologic pathology2014
Vaginal fold histology reduces the variability introduced by vaginal exfoliative cytology in the classification of mouse estrous cycle stages.
Article in Toxicologic pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 38 citations in OpenAlex.
- High-yield induced ovulation in the adult marsupial fat-tailed dunnart (Sminthopsis crassicaudata).Scientific reports · 2026Article
- Advanced Multiscale Attention Network for Estrous Cycle Stage Identification from Rat Vaginal Cytology.Biology · 2025Article
- HIGD1A Alleviates Oxidative Stress Related Ovarian Hypofunction by Enhancing Granulosa Cell Functions via NF-κB/SOD2 Signaling Pathway.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Determination of the rat estrous cycle vased on EfficientNet.Frontiers in veterinary science · 2024Article
- Extracellular Matrix-Based and Electrospun Scaffolding Systems for Vaginal Reconstruction.Bioengineering (Basel, Switzerland) · 2023Review
- A comparative analysis of depressive-like behavior: Exploring sex-related differences and insights.PloS one · 2023Article
- Decrease in ovarian reserve through the inhibition of SIRT1-mediated oxidative phosphorylation.Aging · 2022Article
- A multi-tissue transcriptomic landscape of female mice in estrus and diestrus provides clues for precision medicine.Frontiers in cell and developmental biology · 2022Article
- Effects of spaceflight aboard the International Space Station on mouse estrous cycle and ovarian gene expression.NPJ microgravity · 2021Article
- Comparison of cannabidiol to citalopram in targeting fear memory in female mice.Journal of cannabis research · 2020Article
- Article
- Agonistic activity of tamoxifen, a selective estrogen-receptor modulator (SERM), on arthritic ovariectomized mice.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2017Article
- Loss of Fertility in the Absence of Progesterone Receptor Expression in Kisspeptin Neurons of Female Mice.PloS one · 2016Article
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Authors and funding
5 authors at 1 institution in 1 country.
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Abstract
Vaginal exfoliative cytology is commonly used in biomedical and toxicological research to classify the stages of the rodent estrous cycle. However, mouse vaginal exfoliative cytology is commonly used as a stand-alone tool and has not been evaluated in reference to vaginal histology and serum sex hormone levels. In this study, the direct and Giemsa-stained methods of vaginal exfoliative cytology were compared in reference to vaginal fold histology and serum sex hormone levels. Both methods predicted the estrous stages similarly with mean discordance rates of 55%, 77%, 46%, and 31%, for diestrus, proestrus, estrus, and metestrus, respectively. From these results, we conclude that vaginal exfoliative cytology may be used as a general guide to determine the desired estrous stage end point and that a definitive confirmation of the estrous stage should be obtained from evaluation of vaginal fold histology. Confirmation of the stage of the estrous cycle by vaginal fold histology will decrease the variability otherwise introduced by misclassification of estrous cycle stages with vaginal exfoliative cytology.
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