ReviewCurrent diabetes reports2014
The sum of many parts: potential mechanisms for improvement in glucose homeostasis after bariatric surgery.
Review in Current diabetes reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effect of Bariatric Surgery on Thyroid Function in Obese Patients: a Systematic Review and Meta-Analysis.Obesity surgery · 2017Pooled it
- FGF 19 and Bile Acids Increase Following Roux-en-Y Gastric Bypass but Not After Medical Management in Patients with Type 2 Diabetes.Obesity surgery · 2016Trial
- Trial
- Roles of Gastric Emptying and Gastrointestinal Transit Following Ileal Interposition in Alleviating Diabetes in Goto-Kakizaki Rats.Frontiers in endocrinology · 2022Article
- Biliopancreatic Limb Length of Small Intestinal Bypass in Non-obese Goto-Kakizaki (GK) Rats Correlates with Gastrointestinal Hormones, Adipokines, and Improvement in Type 2 Diabetes.Obesity surgery · 2021Article
- Article
- A retrospective case control study identifies peripheral blood mononuclear cell albumin RNA expression as a biomarker for non-alcoholic fatty liver disease.Langenbeck's archives of surgery · 2020Article
- Prospective study of gut hormone and metabolic changes after laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass.PloS one · 2020Article
- A role for foregut tyrosine metabolism in glucose tolerance.Molecular metabolism · 2019Article
- Sleeve Gastrectomy and Roux-en-Y Gastric Bypass Achieve Similar Early Improvements in Beta-cell Function in Obese Patients with Type 2 Diabetes.Scientific reports · 2019Article
- The gut in the brain: the effects of bariatric surgery on alcohol consumption.Addiction biology · 2017Review
- Environmental/lifestyle factors in the pathogenesis and prevention of type 2 diabetes.BMC medicine · 2017Review
- Circulating Apolipoprotein A-IV presurgical levels are associated with improvement in insulin sensitivity after Roux-en-Y gastric bypass surgery.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2017Article
- Peripheral circadian misalignment: contributor to systemic insulin resistance and potential intervention to improve bariatric surgical outcomes.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Review
- Recent advances in the modification of taste and food preferences following bariatric surgery.Reviews in endocrine & metabolic disorders · 2016Review
- Ranking factors involved in diabetes remission after bariatric surgery using machine-learning integrating clinical and genomic biomarkers.NPJ genomic medicine · 2016Article
- Bile Acids, FXR, and Metabolic Effects of Bariatric Surgery.Journal of obesity · 2016Review
- Clinical Management of Type 2 Diabetes Mellitus after Bariatric Surgery.Current atherosclerosis reports · 2015Review
- Effect of sleeve gastrectomy on thyroid hormone levels.Obesity surgery · 2015Article
- Assessing the obese diabetic patient for bariatric surgery: which candidate do I choose?Diabetes, metabolic syndrome and obesity : targets and therapy · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Bariatric surgery has emerged as the most durably effective treatment of type 2 diabetes (DM). However, the mechanisms governing improvement in glucose homeostasis have yet to be fully elucidated. In this review we discuss the various types of surgical interventions and the multitude of factors that potentially mediate the effects on glycemia, such as altered delivery of nutrients to the distal ileum, duodenal exclusion, gut hormone changes, bile acid reabsorption, and amino acid metabolism. Accumulating evidence that some of these changes seem to be independent of weight loss questions the rationale of using body mass index as the major indication for surgery in diabetic patients. Understanding the complex mechanisms and interactions underlying improved glycemic control could lead to novel therapeutic targets and would also allow for greater individualization of therapy and optimization of surgical outcomes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.