Evidence map›Paper›PMID 24705652›Full record

ReviewNature reviews. Cancer2014

The role of vitamin D in reducing cancer risk and progression.

David Feldman, Aruna V Krishnan, Srilatha Swami, Edward Giovannucci, Brian J Feldman

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06551688 (Influence of Preoperative Vitamin D Level on Postoperative Pain in Breast Cancer Surgery Patients), which is not on this map. Cited by 683 papers, 17 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
683citing papers in PubMed, 17 pooled it
71.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06551688 completednot on this mapstarted 2024, after this paper: background citation

Influence of Preoperative Vitamin D Level on Postoperative Pain in Breast Cancer Surgery Patients: A Prospective Observational Study

TypeobservationalSponsorFayoum UniversityRan2024 to 2025Enrolled184ConditionsCancer Breast, Hypovitaminosis DArmsSerum 25(OH)D level
3 · Its place in the literature

Who cites it

683 citing papers in PubMed, 17 syntheses or guidelines pooled it, 1,292 citations in OpenAlex.

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  20. Impact of Cholecalciferol Supplementation on Radiotherapy Outcomes in Advanced Cervical Cancer.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Trial

623 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

David FeldmanDepartment of Medicine, Division of Endocrinology, Stanford University School of Medicine, Stanford, California 94305, USA.
Aruna V KrishnanDepartment of Medicine, Division of Endocrinology, Stanford University School of Medicine, Stanford, California 94305, USA.
Srilatha SwamiDepartment of Medicine, Division of Endocrinology, Stanford University School of Medicine, Stanford, California 94305, USA.
Edward GiovannucciDepartments of Epidemiology and Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
Brian J FeldmanDepartment of Pediatrics, Division of Pediatric Endocrinology, Stanford University School of Medicine, Stanford, California 94305, USA.
Stanford Medicine · USMassachusetts Department of Public Health · US

Funding

Using Components of the Circadian Clock to Regulate Stem Cell Fate DecisionsDP2OD006740 · OD · STANFORD UNIVERSITY · PI FELDMAN, BRIAN J · 2010 to 2010
$2.4M
NIH HHS DP2OD006740
6 · The paper itself

Abstract

Vitamin D is not really a vitamin but the precursor to the potent steroid hormone calcitriol, which has widespread actions throughout the body. Calcitriol regulates numerous cellular pathways that could have a role in determining cancer risk and prognosis. Although epidemiological and early clinical trials are inconsistent, and randomized control trials in humans do not yet exist to conclusively support a beneficial role for vitamin D, accumulating results from preclinical and some clinical studies strongly suggest that vitamin D deficiency increases the risk of developing cancer and that avoiding deficiency and adding vitamin D supplements might be an economical and safe way to reduce cancer incidence and improve cancer prognosis and outcome.

Indexed as

25-Hydroxyvitamin D3 1-alpha-HydroxylaseBreast NeoplasmsCalcitriolCholecalciferolColonic NeoplasmsDisease ProgressionEndocrine SystemFemaleHumansMaleNeoplasmsNeoplastic Stem CellsPolymorphism, GeneticPrognosisProstatic NeoplasmsRandomized Controlled Trials as Topic25-Hydroxyvitamin D3 1-alpha-HydroxylaseCalcitriolCholecalciferolSteroid HydroxylasesVitamin DVitamin D3 24-Hydroxylase

Identifiers

PMID24705652
OpenAlexW2020994990

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.