ArticlePloS one2014
Mechanisms of nerve capping technique in prevention of painful neuroma formation.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Surgical interventions for the treatment of painful neuroma: a comparative meta-analysis.Pain · 2018Pooled it
- Lateral Femoral Cutaneous Nerve Neuroma Resection and Nerve Capping after Direct Anterior Approach: A Case Report.Journal of orthopaedic case reports · 2026Article
- Regulation of macrophages in the dorsal root ganglion through TGF-β1 inhibits painful traumatic neuroma.Journal of translational medicine · 2025Article
- Improving outcomes in traumatic peripheral nerve injuries to the upper extremity.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024Review
- Traumatic neuromas with hemangiomas of diverse morphology in the left upper arm: a case description.Quantitative imaging in medicine and surgery · 2024Article
- The Use of Nerve Caps after Nerve Transection in Headache Surgery: Cadaver and Case Reports.Plastic and reconstructive surgery. Global open · 2023Article
- Nerve Defect Treatment with a Capping Hydroxyethyl Cellulose/Soy Protein Isolate Sponge Conduit for Painful Neuroma Prevention.ACS omega · 2023Article
- Preventive Effect of Local Lidocaine Administration on the Formation of Traumatic Neuroma.Journal of clinical medicine · 2023Article
- Myelin-associated glycoprotein combined with chitin conduit inhibits painful neuroma formation after sciatic nerve transection.Neural regeneration research · 2022Article
- Surgical treatment of symptomatic neuromas: a feasibility study using the NEUROCAP® bioresorbable nerve capping device.The Journal of hand surgery, European volume · 2022Article
- Traumatic neuromas of peripheral nerves: Diagnosis, management and future perspectives.Frontiers in neurology · 2022Review
- Exploring the Correlation Between the Regulation of Macrophages by Regulatory T Cells and Peripheral Neuropathic Pain.Frontiers in neuroscience · 2022Article
- Surgical Approaches for Prevention of Neuroma at Time of Peripheral Nerve Injury.Frontiers in surgery · 2022Review
- Aligned nanofiber nerve conduits inhibit alpha smooth muscle actin expression and collagen proliferation by suppressing TGF-β1/SMAD signaling in traumatic neuromas.Experimental and therapeutic medicine · 2021Article
- Peripheral nerve tumors of the hand: Clinical features, diagnosis, and treatment.World journal of clinical cases · 2020Review
- Treatment of Neuroma-induced Chronic Pain and Management of Nerve Defects with Processed Nerve Allografts.Plastic and reconstructive surgery. Global open · 2019Article
- Metformin relieves neuropathic pain after spinal nerve ligation via autophagy flux stimulation.Journal of cellular and molecular medicine · 2019Article
- Surgical Algorithm for Neuroma Management: A Changing Treatment Paradigm.Plastic and reconstructive surgery. Global open · 2018Article
- Painful Terminal Neuroma Prevention by Capping PRGD/PDLLA Conduit in Rat Sciatic Nerves.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2018Article
- Analysis of regeneration- and myelination-associated proteins in human neuroma in continuity and discontinuity.Acta neurochirurgica · 2018Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nerve capping techniques have been introduced as a promising treatment modality for the treatment of painful neuroma with varied outcomes; however, its exact mechanism is still unknown. RhoA is one of the members of the RAS superfamily of GTPases that operate as molecular switches and plays an important role in peripheral nerve regeneration. Our aim was to investigate the structural and morphologic mechanisms by which the nerve capping technique prevents the formation of painful neuromas after neuroectomy. We also hoped to provide a theoretical basis for this treatment approach. An aligned nanofiber conduit was used for the capping procedure and the sciatic nerve of Sprague-Dawley rats was selected as the animal model. Behavioral analysis, extent of neuroma formation, histological assessment, expressions of pain markers of substance P and c-fos, molecular biological changes as well as ultrastructural features were investigated and compared with the findings in a no-capping control group. The formation of traumatic neuromas was significantly inhibited in the capping group with relatively "normal" structural and morphological features and no occurrence of autotomy and significantly lower expression of pain markers compared to the no-capping group. The gene expression of RhoA was consistently in a higher level in the capping group within 8 weeks after surgery. This study shows that capping technique will alter the regeneration state of transected nerves and reduce painful neuroma formation, indicating a promising approach for the treatment of painful neuroma. The initiation of the "regenerative brake" induced by structural as well as morphological improvements in the severed nerve is theorized to be most likely a key mechanism for the capping technique in the prevention of painful neuroma formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.