Evidence map›Paper›PMID 24705444›Full record

SynthesisPloS one2014

Combined effects of TGFB1 +869 T/C and +915 G/C polymorphisms on acute rejection risk in solid organ transplant recipients: a systematic review and meta-analysis.

Yu-Zheng Ge, Ran Wu, Tian-Ze Lu, Rui-Peng Jia, Ming-Hao Li, Xiao-Fei Gao, Xiao-Min Jiang, Xian-Bo Zhu, Liang-Peng Li, Si-Jia Tan and 3 more

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. A functionalClinical kidney journal · 2022
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Yu-Zheng GeCenter for Renal Transplantation, Nanjing First Hospital, Nanjing Medical University, Nanjing, China; Department of Urology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Ran WuCenter for Renal Transplantation, Nanjing First Hospital, Nanjing Medical University, Nanjing, China; Department of Urology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Tian-Ze LuCenter for Renal Transplantation, Nanjing First Hospital, Nanjing Medical University, Nanjing, China; Department of Urology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Rui-Peng JiaCenter for Renal Transplantation, Nanjing First Hospital, Nanjing Medical University, Nanjing, China; Department of Urology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Ming-Hao LiCenter for Renal Transplantation, Nanjing First Hospital, Nanjing Medical University, Nanjing, China; Department of Urology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Xiao-Fei GaoDepartment of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Xiao-Min JiangDepartment of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Xian-Bo ZhuDepartment of General Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Liang-Peng LiDepartment of Cardiothoracic Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Si-Jia TanCenter for Renal Transplantation, Nanjing First Hospital, Nanjing Medical University, Nanjing, China; Department of Urology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Qun SongCenter for Renal Transplantation, Nanjing First Hospital, Nanjing Medical University, Nanjing, China; Department of Urology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Wen-Cheng LiCenter for Renal Transplantation, Nanjing First Hospital, Nanjing Medical University, Nanjing, China; Department of Urology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Jia-Geng ZhuCenter for Renal Transplantation, Nanjing First Hospital, Nanjing Medical University, Nanjing, China; Department of Urology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Nanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTransforming growth factor-beta 1(TGF-β1) is involved in the development of acute rejection (AR) episodes in solid organ transplant recipients; and a number of studies have been conducted to investigate the combined effects of human TGF-β1 gene (TGFB1) +869 T/C and +915 G/C polymorphisms on AR risk. However, the results obtained are inconclusive.

methodsEligible studies that investigated the haplotypic association between TGFB1 +869 T/C and +915 G/C polymorphisms and AR risk were comprehensively searched in the PUBMED, EMBASE, China National Knowledge Infrastructure, and Wanfang Database. Statistical analyses were performed by using STATA 12.0 and Review Manager 5.0.

resultsFourteen eligible studies with 565 AR cases and 1219 non-AR cases were included. Overall, a significantly decreased risk was detected in patients carried with intermediate producer (IP) haplotypes (T/C G/C, T/T G/C, and C/C G/G) and/or low producer (LP) haplotypes (C/C G/C, C/C C/C, T/T C/C, and T/C C/C) compared with high producer (HP) haplotypes (T/T G/G and T/C G/G; IP vs. HP: OR = 0.75, 95% CI, 0.58-0.96, P heterogeneity  = 0.238; IP/LP vs. HP: OR  = 0.77, 95% CI, 0.61-0.98, P heterogeneity  = 0.144). In addition, subgroup analysis by transplant types demonstrated a similar association in patients receiving heart transplant (IP vs. HP: OR  = 0.32, 95% CI, 0.14-0.73, P heterogeneity  = 0.790; IP/LP vs. HP: OR  = 0.41, 95% CI, 0.20-0.85, P heterogeneity  = 0.320).

conclusionsThe current meta-analysis and systematic review indicated that recipient TGFB1 HP haplotypes were significantly associated with an increased risk for AR in solid organ transplant recipients, particularly patients receiving cardiac allograft.

Indexed as

Graft RejectionHaplotypesHumansOdds RatioOrgan TransplantationPolymorphism, Single NucleotideTransforming Growth Factor beta1TGFB1 protein, humanTransforming Growth Factor beta1

Identifiers

PMID24705444
PMCPMC3976347
OpenAlexW1985304704

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.