ArticlePloS one2014
Effects of Fortunella margarita fruit extract on metabolic disorders in high-fat diet-induced obese C57BL/6 mice.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 44 citations in OpenAlex.
- Kumquat Fruit Administration Counteracts Dysmetabolism-Related Neurodegeneration and the Associated Brain Insulin Resistance in the High-Fat Diet-Fed Mice.International journal of molecular sciences · 2025Article
- Unraveling Obesity: Transgenerational Inheritance, Treatment Side Effects, Flavonoids, Mechanisms, Microbiota, Redox Balance, and Bioavailability-A Narrative Review.Antioxidants (Basel, Switzerland) · 2023Review
- Effects of fruits and vegetables on gut microbiota in a mouse model of metabolic syndrome induced by high-fat diet.Food science & nutrition · 2023Article
- Article
- Drying kinetics and physicochemical properties of kumquat under hot air and air-impingement jet dryings.Food science and biotechnology · 2022Article
- An Avocado Extract Enriched in Mannoheptulose Prevents the Negative Effects of a High-Fat Diet in Mice.Nutrients · 2021Article
- Use of an Extract ofNutrients · 2019Article
- Notoginsenoside Fe suppresses diet induced obesity and activates paraventricular hypothalamic neurons.RSC advances · 2019Article
- Flavonoids as inducers of white adipose tissue browning and thermogenesis: signalling pathways and molecular triggers.Nutrition & metabolism · 2019Review
- Anti-obesity effect of robusta fermented withExperimental and therapeutic medicine · 2017Article
- Plantago asiatica L. Seed Extract Improves Lipid Accumulation and Hyperglycemia in High-Fat Diet-Induced Obese Mice.International journal of molecular sciences · 2017Article
- Phenolic compounds and biological activities of small-size citrus: Kumquat and calamondin.Journal of food and drug analysis · 2017Review
- Ameliorative effects of lutein on non-alcoholic fatty liver disease in rats.World journal of gastroenterology · 2015Article
- Network pharmacology-based antioxidant effect study of zhi-zi-da-huang decoction for alcoholic liver disease.Evidence-based complementary and alternative medicine : eCAM · 2015Article
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Authors and funding
13 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
introductionObesity is a nutritional disorder associated with many health problems such as dyslipidemia, type 2 diabetes and cardiovascular diseases. In the present study, we investigated the anti-metabolic disorder effects of kumquat (Fortunella margarita Swingle) fruit extract (FME) on high-fat diet-induced C57BL/6 obese mice.
methodsThe kumquat fruit was extracted with ethanol and the main flavonoids of this extract were analyzed by HPLC. For the preventive experiment, female C57BL/6 mice were fed with a normal diet (Chow), high-fat diet (HF), and high-fat diet with 1% (w/w) extract of kumquat (HF+FME) for 8 weeks. For the therapeutic experiment, female C57BL/6 mice were fed with high-fat diet for 3 months to induce obesity. Then the obese mice were divided into two groups randomly, and fed with HF or HF+FME for another 2 weeks. Body weight and daily food intake amounts were recorded. Fasting blood glucose, glucose tolerance test, insulin tolerance test, serum and liver lipid levels were assayed and the white adipose tissues were imaged. The gene expression in mice liver and brown adipose tissues were analyzed with a quantitative PCR assay.
resultsIn the preventive treatment, FME controlled the body weight gain and the size of white adipocytes, lowered the fasting blood glucose, serum total cholesterol (TC), serum low density lipoprotein cholesterol (LDL-c) levels as well as liver lipid contents in high-fat diet-fed C57BL/6 mice. In the therapeutic treatment, FME decreased the serum triglyceride (TG), serum TC, serum LDL-c, fasting blood glucose levels and liver lipid contents, improved glucose tolerance and insulin tolerance. Compared with the HF group, FME significantly increased the mRNA expression of PPARα and its target genes.
conclusionOur study suggests that FME may be a potential dietary supplement for preventing and ameliorating the obesity and obesity-related metabolic disturbances.
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