Evidence map›Paper›PMID 24705385›Full record

ArticlePloS one2014

Challenges in translational research: the views of addiction scientists.

Jenny E Ostergren, Rachel R Hammer, Molly J Dingel, Barbara A Koenig, Jennifer B McCormick

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Rising to the challenge: Value based research for Orthopaedic ailments.Journal of clinical orthopaedics and trauma · 2022
    Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 1 country.

Jenny E OstergrenDepartment of Health Behavior and Health Education, University of Michigan, Ann Arbor, Michigan, United States of America.
Rachel R HammerBiomedical Ethics Research Unit and Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America.
Molly J DingelCenter for Learning Innovation, University of Minnesota Rochester, Rochester, Minnesota, United States of America.
Barbara A KoenigDepartments of Social & Behavioral Sciences, and Anthropology, History, and Social Medicine, University of California San Francisco, San Francisco, California, United States of America.
Jennifer B McCormickDivisions of General Internal Medicine & Health Care Policy Research, and Biomedical Ethics Program, Mayo Clinic, Rochester, Minnesota, United States of America.
Mayo Clinic · USMayo Clinic in Florida · USMichigan United · USUniversity of California, San Francisco · USUniversity of Minnesota Rochester · US

Funding

MAYO CLINIC CENTER FOR TRANSLATIONAL SCIENCE ACTIVITIESUL1RR024150 · NCRR · MAYO CLINIC ROCHESTER · PI RIZZA, ROBERT A. · 2006 to 2011
$66.4M
Translating Addiction Genomics Research into Practice: Examining Ethics & PolicyR01DA014577 · NIDA · STANFORD UNIVERSITY · PI MCCORMICK, JENNIFER BLAIR · 2002 to 2010
$2.0M
Center for Transdisciplinary ELSI Research in Translational GenomicsP20HG007243 · NHGRI · KAISER FOUNDATION RESEARCH INSTITUTE · PI HARRIS-WAI, JULIE NOEL, KOENIG, BARBARA A. · 2013 to 2016
$958k
NCRR NIH HHS UL1 RR024150NHGRI NIH HHS P20 HG007243NIDA NIH HHS R01 DA014577
6 · The paper itself

Abstract

objectivesTo explore scientists' perspectives on the challenges and pressures of translating research findings into clinical practice and public health policy.

methodsWe conducted semi-structured interviews with a purposive sample of 20 leading scientists engaged in genetic research on addiction. We asked participants for their views on how their own research translates, how genetic research addresses addiction as a public health problem and how it may affect the public's view of addiction.

resultsMost scientists described a direct translational route for their research, positing that their research will have significant societal benefits, leading to advances in treatment and novel prevention strategies. However, scientists also pointed to the inherent pressures they feel to quickly translate their research findings into actual clinical or public health use. They stressed the importance of allowing the scientific process to play out, voicing ambivalence about the recent push to speed translation.

conclusionsHigh expectations have been raised that biomedical science will lead to new prevention and treatment modalities, exerting pressure on scientists. Our data suggest that scientists feel caught in the push for immediate applications. This overemphasis on rapid translation can lead to technologies and applications being rushed into use without critical evaluation of ethical, policy, and social implications, and without balancing their value compared to public health policies and interventions currently in place.

Indexed as

Behavior, AddictiveBiomedical ResearchPerceptionTranslational Research, BiomedicalFemaleHumansInterviews as TopicLaboratory PersonnelMaleResearch Personnel

Identifiers

PMID24705385
PMCPMC3976268
OpenAlexW1984966742

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.