Evidence map›Paper›PMID 24705358›Full record

ArticleInternational journal of environmental research and public health2014

Association between Kawasaki disease and autism: a population-based study in Taiwan.

Ho-Chang Kuo, Chung-Min Wu, Wei-Pin Chang, Chun-Nan Kuo, Deniz Yeter, Chun-Yi Lin, Jei-Tsung Pai, Ying-Chen Chi, Chia-Hsien Lin, Liang-Jen Wang and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of environmental research and public health, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Observational
  5. Article
  6. Epigenetic Effect of Environmental Factors on Autism Spectrum Disorders.International journal of environmental research and public health · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 1 country.

Ho-Chang KuoDepartment of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan. erickuo48@yahoo.com.tw.
Chung-Min WuDepartment of Business Management, National Taipei University of Technology, Taipei 106, Taiwan. cmwu@ntut.edu.tw.
Wei-Pin ChangDepartment of Healthcare Management, Yuanpei University, HsinChu 300, Taiwan. wpchang@mail.ypu.edu.tw.
Chun-Nan KuoDepartment of Clinical Pharmacy, School of Pharmacy, Taipei Medical University, Taipei 110, Taiwan. rencouter@gmail.com.
Deniz YeterShawnee, Kansas, 66226, USA. deniz.yeter@gmx.de.
Chun-Yi LinDepartment of Healthcare Management, Yuanpei University, HsinChu 300, Taiwan. elaine_lin76@ymail.com.
Jei-Tsung PaiDepartment of Healthcare Management, Yuanpei University, HsinChu 300, Taiwan. reitrong@mail.ypu.edu.tw.
Ying-Chen ChiDepartment of Education & Research, Taipei City Hospital, Taipei 106, Taiwan. a0130@tpech.gov.tw.
Chia-Hsien LinDepartment of Health Industry Management, School of Health Care Management, Kainan University, Taoyuan 338, Taiwan. g870615@gmail.com.
Liang-Jen WangDepartment of Child and Adolescent Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan. wangliangjen@gmail.com.
Wei-Chiao ChangDepartment of Clinical Pharmacy, School of Pharmacy, Taipei Medical University, Taipei 110, Taiwan. rencouter@gmail.com.
Chang Gung University · TWKainan University · TWKaohsiung Medical University · TWNational Taipei University of Technology · TWTaipei City Hospital · TWWan Fang Hospital · TWYuanpei University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe association between Kawasaki disease and autism has rarely been studied in Asian populations. By using a nationwide Taiwanese population-based claims database, we tested the hypothesis that Kawasaki disease may increase the risk of autism in Taiwan. MATERIALS AND

methodsOur study cohort consisted of patients who had received the diagnosis of Kawasaki disease (ICD-9-CM: 446.1) between 1997 and 2005 (N = 563). For a comparison cohort, five age- and gender-matched control patients for every patient in the study cohort were selected using random sampling (N = 2,815). All subjects were tracked for 5 years from the date of cohort entry to identify whether they had developed autism (ICD-9-CM code 299.0) or not. Cox proportional hazard regressions were then performed to evaluate 5-year autism-free survival rates.

resultsThe main finding of this study was that patients with Kawasaki disease seem to not be at increased risk of developing autism. Of the total patients, four patients developed autism during the 5-year follow-up period, among whom two were Kawasaki disease patients and two were in the comparison cohort. Further, the adjusted hazard ratios (AHR) (AHR: 4.81; 95% confidence interval: 0.68-34.35; P = 0.117) did not show any statistical significance between the Kawasaki disease group and the control group during the 5-year follow-up.

conclusionOur study indicated that patients with Kawasaki disease are not at increased risk of autism.

Indexed as

Autistic DisorderChild, PreschoolCohort StudiesFemaleHumansInfantInfant, NewbornMaleMucocutaneous Lymph Node SyndromePrevalenceRiskTaiwan

Identifiers

PMID24705358
PMCPMC4025040
OpenAlexW2074980549

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.