ArticleGenes2014
Reading and language disorders: the importance of both quantity and quality.
Article in Genes, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Oral language deficits in familial dyslexia: A meta-analysis and review.Psychological bulletin · 2016Pooled it
- Whole-exome sequencing in children with dyslexia implicates rare variants in CLDN3 and ion channel genes.Human genetics · 2025Article
- Whole exome sequencing identifies ABHD14A and MRNIP as novel candidate genes for developmental language disorder.Scientific reports · 2025Article
- Charting the Shift: Age as a Moderator of the Genetic and Environmental Influences on Reading.Scientific studies of reading : the official journal of the Society for the Scientific Study of Reading · 2025Article
- Phonological awareness mediates the relationship between DCDC2 and reading performance with home environment.NPJ science of learning · 2024Article
- Genome-wide analyses of individual differences in quantitatively assessed reading- and language-related skills in up to 34,000 people.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Insights into Dyslexia Genetics Research from the Last Two Decades.Brain sciences · 2021Review
- Identifying interactive biological pathways associated with reading disability.Brain and behavior · 2020Article
- Article
- Phonological memory problems are magnified in children from language minority homes when predicting reading disability.Journal of child language · 2020Article
- The dyslexia susceptibility KIAA0319 gene shows a specific expression pattern during zebrafish development supporting a role beyond neuronal migration.The Journal of comparative neurology · 2019Article
- Neuroimaging genetics studies of specific reading disability and developmental language disorder: A review.Language and linguistics compass · 2019Article
- The neuronal migration hypothesis of dyslexia: A critical evaluation 30 years on.The European journal of neuroscience · 2018Review
- Stage 2 Registered Report: Variation in neurodevelopmental outcomes in children with sex chromosome trisomies: testing the double hit hypothesis.Wellcome open research · 2018Article
- Next-generation DNA sequencing identifies novel gene variants and pathways involved in specific language impairment.Scientific reports · 2017Article
- Behavioral and Molecular Genetics of Reading-Related AM and FM Detection Thresholds.Behavior genetics · 2017Article
- Further evidence for a parent-of-origin effect at the NOP9 locus on language-related phenotypes.Journal of neurodevelopmental disorders · 2016Article
- Common Genetic Variants in FOXP2 Are Not Associated with Individual Differences in Language Development.PloS one · 2016Article
- The interface between genetics and psychology: lessons from developmental dyslexia.Proceedings. Biological sciences · 2015Review
- Lack of replication for the myosin-18B association with mathematical ability in independent cohorts.Genes, brain, and behavior · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Reading and language disorders are common childhood conditions that often co-occur with each other and with other neurodevelopmental impairments. There is strong evidence that disorders, such as dyslexia and Specific Language Impairment (SLI), have a genetic basis, but we expect the contributing genetic factors to be complex in nature. To date, only a few genes have been implicated in these traits. Their functional characterization has provided novel insight into the biology of neurodevelopmental disorders. However, the lack of biological markers and clear diagnostic criteria have prevented the collection of the large sample sizes required for well-powered genome-wide screens. One of the main challenges of the field will be to combine careful clinical assessment with high throughput genetic technologies within multidisciplinary collaborations.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.