ArticleGenes2013
The genetics of diabetic nephropathy.
Article in Genes, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Methylenetetrahydrofolate reductase genetic polymorphism and the risk of diabetic nephropathy in type 2 diabetic patients.Medicine · 2020Pooled it
- Association between E469K polymorphism in the ICAM1 gene and the risk of diabetic nephropathy: a meta-analysis.Lipids in health and disease · 2018Pooled it
- Genetic risk score for risk prediction of diabetic nephropathy in Han Chinese type 2 diabetes patients.Scientific reports · 2019Trial
- A lipid metabolism-based gene signature defines diagnosis and molecular heterogeneity in diabetic nephropathy.Iranian journal of basic medical sciences · 2026Article
- The rs3844492/ARHGAP22 and rs741301/ELMO1 polymorphisms are associated with changes in laboratory markers of renal damage among patients with type 2 diabetes mellitus.Archives of endocrinology and metabolism · 2025Article
- Association of the interaction between interleukin-1β gene polymorphism and smoking status with the diabetic nephropathy risk in a Chinese Han population.Diabetology & metabolic syndrome · 2025Article
- The KDR Gene rs2071559 and the VEGF Gene rs6921438 May Be Associated with Diabetic Nephropathy in Caucasians with Type 2 Diabetes Mellitus.International journal of molecular sciences · 2024Article
- Impact of magnesium sulfate therapy in improvement of renal functions in high fat diet-induced diabetic rats and their offspring.Scientific reports · 2023Article
- The A allele of the rs759853 single nucleotide polymorphism in theArchives of endocrinology and metabolism · 2022Article
- Gender Differences in Genetic Associations of RAB38 with Urinary Protein-to-Creatinine Ratio (UPCR) Levels in Diabetic Nephropathy Patients.Journal of personalized medicine · 2020Article
- MiR-30e-5p and MiR-15a-5p Expressions in Plasma and Urine of Type 1 Diabetic Patients With Diabetic Kidney Disease.Frontiers in genetics · 2019Article
- The cellular selection between apoptosis and autophagy: roles of vitamin D, glucose and immune response in diabetic nephropathy.Endocrine · 2017Article
- Rutin suppresses high glucose-induced ACTA2 and p38 protein expression in diabetic nephropathy.Experimental and therapeutic medicine · 2017Article
- Association of Diabetes Related Complications with Heart Rate Variability among a Diabetic Population in the UAE.PloS one · 2017Article
- Renoprotective Effects of Atorvastatin in Diabetic Mice: Downregulation of RhoA and Upregulation of Akt/GSK3.PloS one · 2016Article
- The association of previously reported polymorphisms for microvascular complications in a meta-analysis of diabetic retinopathy.Human genetics · 2015Review
- Combination of Angiotensin Converting Enzyme Insertion/Deletion (I/D) (rs4646994) and VEGF Polymorphism (+405G/C; rs2010963) Synergistically Associated With the Development, of Albuminuria in Iranian Patients With Type 2 Diabetes.Iranian Red Crescent medical journal · 2015Article
- Identifying Common Genetic Risk Factors of Diabetic Neuropathies.Frontiers in endocrinology · 2015Review
- Genetic modulation of diabetic nephropathy among mouse strains with Ins2 Akita mutation.Physiological reports · 2014Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Up to 40% of patients with type 1 and type 2 diabetes will develop diabetic nephropathy (DN), resulting in chronic kidney disease and potential organ failure. There is evidence for a heritable genetic susceptibility to DN, but despite intensive research efforts the causative genes remain elusive. Recently, genome-wide association studies have discovered several novel genetic variants associated with DN. The identification of such variants may potentially allow for early identification of at risk patients. Here we review the current understanding of the key molecular mechanisms and genetic architecture of DN, and discuss the merits of employing an integrative approach to incorporate datasets from multiple sources (genetics, transcriptomics, epigenetic, proteomic) in order to fully elucidate the genetic elements contributing to this serious complication of diabetes.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.