Trial reportNeuroImage2014
Control of nucleus accumbens activity with neurofeedback.
Trial report in NeuroImage, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Frontostriatal circuitry as a target for fMRI-based neurofeedback interventions: A systematic review.Frontiers in human neuroscience · 2022Pooled it
- Can we predict real-time fMRI neurofeedback learning success from pretraining brain activity?Human brain mapping · 2020Pooled it
- A Guide to Literature Informed Decisions in the Design of Real Time fMRI Neurofeedback Studies: A Systematic Review.Frontiers in human neuroscience · 2020Pooled it
- Neuroinflammation following anti-parkinsonian drugs in early Parkinson's disease: a longitudinal PET study.Scientific reports · 2024Trial
- Self-regulation of the dopaminergic reward circuit in cocaine users with mental imagery and neurofeedback.EBioMedicine · 2018Trial
- Targeting the dopaminergic midbrain with precision 7-Tesla biofeedback training in depression: A proof-of-principle randomized controlled trial.Molecular psychiatry · 2026Article
- Aesthetic experiences across visual perception and mental imagery: Behaviorally indistinguishable, neurally distinct.iScience · 2025Article
- Article
- Article
- The Stress Phenotyping Framework: A multidisciplinary biobehavioral approach for assessing and therapeutically targeting maladaptive stress physiology.Stress (Amsterdam, Netherlands) · 2024Review
- Self-regulating arousal via pupil-based biofeedback.Nature human behaviour · 2024Article
- Development and validation of an fMRI-informed EEG model of reward-related ventral striatum activation.NeuroImage · 2023Article
- Testing the efficacy of real-time fMRI neurofeedback for training people who smoke daily to upregulate neural responses to nondrug rewards.Cognitive, affective & behavioral neuroscience · 2023Article
- Successful modulation of temporoparietal junction activity and stimulus-driven attention by fNIRS-based neurofeedback-A randomized controlled proof-of-concept study.Imaging neuroscience (Cambridge, Mass.) · 2023Article
- Neurofeedback-dependent influence of the ventral striatum using a working memory paradigm targeting the dorsolateral prefrontal cortex.Frontiers in behavioral neuroscience · 2023Article
- Analysis of individual differences in neurofeedback training illuminates successful self-regulation of the dopaminergic midbrain.Communications biology · 2022Article
- Nucleus Accumbens Response to Reward among Children with a Family History of Alcohol Use Problems: Convergent Findings from the ABCD StudyBrain sciences · 2022Article
- Toward a neurocircuit-based taxonomy to guide treatment of obsessive-compulsive disorder.Molecular psychiatry · 2021Review
- Quality and denoising in real-time functional magnetic resonance imaging neurofeedback: A methods review.Human brain mapping · 2020Review
- Mesocorticolimbic Interactions Mediate fMRI-Guided Regulation of Self-Generated Affective States.Brain sciences · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The nucleus accumbens (NAcc) plays critical roles in healthy motivation and learning, as well as in psychiatric disorders (including schizophrenia and attention deficit hyperactivity disorder). Thus, techniques that confer control of NAcc activity might inspire new therapeutic interventions. By providing second-to-second temporal resolution of activity in small subcortical regions, functional magnetic resonance imaging (fMRI) can resolve online changes in NAcc activity, which can then be presented as "neurofeedback." In an fMRI-based neurofeedback experiment designed to elicit NAcc activity, we found that subjects could increase their own NAcc activity, and that display of neurofeedback significantly enhanced their ability to do so. Subjects were not as capable of decreasing their NAcc activity, however, and enhanced control did not persist after subsequent removal of neurofeedback. Further analyses suggested that individuals who recruited positive aroused affect were better able to increase NAcc activity in response to neurofeedback, and that NAcc neurofeedback also elicited functionally correlated activity in the medial prefrontal cortex. Together, these findings suggest that humans can modulate their own NAcc activity and that fMRI-based neurofeedback may augment their efforts. The observed association between positive arousal and effective NAcc control further supports an anticipatory affect account of NAcc function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.