ArticleNature communications2014
Crystal structure of an amphiphilic foldamer reveals a 48-mer assembly comprising a hollow truncated octahedron.
Article in Nature communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Dual Photo- and pH-Responsive Foldamer Metallogels.Journal of the American Chemical Society · 2026Article
- Parametrization of βJournal of chemical information and modeling · 2026Article
- Comparative Study of Molecular Mechanics Force Fields for β-Peptidic Foldamers: Folding and Self-Association.Journal of chemical information and modeling · 2023Article
- Computational Design of Single-Peptide Nanocages with Nanoparticle Templating.Molecules (Basel, Switzerland) · 2022Article
- Membrane active Janus-oligomers of βChemical science · 2020Article
- Optimizing side chains for crystal growth from water: a case study of aromatic amide foldamers.Chemical science · 2017Article
- Surfactant-facilitated crystallisation of water-soluble foldamers.Chemical science · 2016Article
- Macromolecular Crystallography for Synthetic Abiological Molecules: Combining xMDFF and PHENIX for Structure Determination of Cyanostar Macrocycles.Journal of the American Chemical Society · 2015Article
- Structure of a designed protein cage that self-assembles into a highly porous cube.Nature chemistry · 2014Article
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Authors and funding
6 authors.
Funding
Abstract
Foldamers provide an attractive medium to test the mechanisms by which biological macromolecules fold into complex three-dimensional structures, and ultimately to design novel protein-like architectures with properties unprecedented in nature. Here, we describe a large cage-like structure formed from an amphiphilic arylamide foldamer crystallized from aqueous solution. Forty-eight copies of the foldamer assemble into a 5-nm cage-like structure, an omnitruncated octahedron filled with well-ordered ice-like water molecules. The assembly is stabilized by a mix of arylamide stacking interaction, hydrogen bonding and hydrophobic forces. The omnitruncated octahedra tessellate to form a cubic crystal. These findings may provide an important step towards the design of nanostructured particles resembling spherical viruses.
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