Trial reportEuropean journal of histochemistry : EJH2014
Immunohistochemical analysis of matrix metalloproteinase-13 in human caries dentin.
Trial report in European journal of histochemistry : EJH, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex vivo studies.Frontiers in cellular and infection microbiology · 2023Pooled it
- Allelic and Genotypic Distribution ofClinics and practice · 2025Article
- Dentin Matrix Metalloproteinases: A Futuristic Approach Toward Dentin Repair and Regeneration.Cureus · 2022Review
- The Critical Role of MMP13 in Regulating Tooth Development and Reactionary Dentinogenesis Repair Through the Wnt Signaling Pathway.Frontiers in cell and developmental biology · 2022Article
- Dentine matrix metalloproteinases as potential mediators of dentine regeneration.European cells & materials · 2021Review
- The association between genetic polymorphisms in matrix metalloproteinases and caries experience.Clinical oral investigations · 2021Article
- Article
- Differentially Expressed Salivary Proteins in Dental Caries Patients.BioMed research international · 2021Article
- Gliclazide reduced oxidative stress, inflammation, and bone loss in an experimental periodontal disease model.Journal of applied oral science : revista FOB · 2019Article
- Expression of matrix metalloproteinase-8 and matrix metalloproteinase-13 in mast cells of human periapical lesions.International journal of clinical and experimental pathology · 2018Article
- Is there still room for novelty, in histochemical papers?European journal of histochemistry : EJH · 2016Review
- Histochemistry in biology and medicine: a message from the citing journals.European journal of histochemistry : EJH · 2015Review
- Apoptosis activation in human carious dentin. An immunohistochemical study.European journal of histochemistry : EJH · 2015Article
- Impact of Histochemistry on biomedical research: looking through the articles published in a long-established histochemical journal.European journal of histochemistry : EJH · 2014Article
- Immunocytochemical detection of dentin matrix proteins in primary teeth from patients with dentinogenesis imperfecta associated with osteogenesis imperfecta.European journal of histochemistry : EJH · 2014Article
- Role of matrix metalloproteinases in dental caries, pulp and periapical inflammation: An overview.Journal of oral biology and craniofacial researchReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The immunoexpression profile of matrix metalloproteinase-13 was investigated for the first time in dentin of human caries and healthy teeth. Twelve permanent premolars (10 caries and 2 sound) were decalcified in ethylenediaminetetraacetic acid and processed for embedding in paraffin wax. Sections 3-4 µm in thickness were cut and processed for immunohistochemistry. A mouse monoclonal anti-metalloproteinase-13 antibody was used for localisation using an immunoperoxidase technique. Dentinal immunoreactivity was detected in all teeth; it was weak in sound teeth and strong close to the caries area. These in vivo findings suggest a role for metalloproteinase-13 in the development and progression of adult human dental tissue disorders.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.