Evidence map›Paper›PMID 24704972›Full record

ReviewFree radical biology & medicine2014

Natural forms of vitamin E: metabolism, antioxidant, and anti-inflammatory activities and their role in disease prevention and therapy.

Qing Jiang

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Free radical biology & medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 373 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
373citing papers in PubMed, 8 pooled it
23.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

373 citing papers in PubMed, 8 syntheses or guidelines pooled it, 872 citations in OpenAlex.

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313 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Qing JiangDepartment of Nutrition Science, Purdue University, West Lafayette, IN 47907, USA. Electronic address: qjiang@purdue.edu.
Purdue University West Lafayette · US

Funding

Anti-inflammatory mechanisms, pharmacokinetics of novel metabolites of vitamin ER01AT006882 · NCCIH · PURDUE UNIVERSITY · PI JIANG, QING · 2011 to 2012
$607k
The Role of a Novel Vitamin E Metabolite in Colon Cancer Prevention and TherapyR21CA152588 · NCI · PURDUE UNIVERSITY · PI JIANG, QING · 2011 to 2012
$368k
NCCIH NIH HHS R01 AT006882NCCIH NIH HHS R01AT006882NCI NIH HHS R21 CA152588NCI NIH HHS R21CA152588
6 · The paper itself

Abstract

The vitamin E family consists of four tocopherols and four tocotrienols. α-Tocopherol (αT) is the predominant form of vitamin E in tissues and its deficiency leads to ataxia in humans. However, results from many clinical studies do not support a protective role of αT in disease prevention in people with adequate nutrient status. On the other hand, recent mechanistic studies indicate that other forms of vitamin E, such as γ-tocopherol (γT), δ-tocopherol, and γ-tocotrienol, have unique antioxidant and anti-inflammatory properties that are superior to those of αT in prevention and therapy against chronic diseases. These vitamin E forms scavenge reactive nitrogen species, inhibit cyclooxygenase- and 5-lipoxygenase-catalyzed eicosanoids, and suppress proinflammatory signaling such as NF-κB and STAT3/6. Unlike αT, other vitamin E forms are significantly metabolized to carboxychromanols via cytochrome P450-initiated side-chain ω-oxidation. Long-chain carboxychromanols, especially 13'-carboxychromanols, are shown to have stronger anti-inflammatory effects than unmetabolized vitamins and may therefore contribute to the beneficial effects of vitamin E forms in vivo. Consistent with mechanistic findings, animal and human studies show that γT and tocotrienols may be useful against inflammation-associated diseases. This review focuses on non-αT forms of vitamin E with respect to their metabolism, anti-inflammatory effects and mechanisms, and in vivo efficacy in preclinical models as well as human clinical intervention studies.

Indexed as

AnimalsAnti-Inflammatory AgentsAntioxidantsHumansVitamin EAnti-Inflammatory AgentsAntioxidantsVitamin E5-LipoxygenaseAsthmaCancerCyclooxygenaseFree radicalsInflammationLong-chain carboxychromanolLung injuryTocopherolTocotrienol

Identifiers

PMID24704972
PMCPMC4120831
OpenAlexW2052084403

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.