Evidence map›Paper›PMID 24704828›Full record

ArticleOncogene2015

c-Myc-mediated repression of miR-15-16 in hypoxia is induced by increased HIF-2α and promotes tumor angiogenesis and metastasis by upregulating FGF2.

G Xue, H-L Yan, Y Zhang, L-Q Hao, X-T Zhu, Q Mei, S-H Sun

Abstract read
PubMed Publisher
In one paragraph

Article in Oncogene, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.

  1. Pooled it
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  10. Potassium Channels, Glucose Metabolism and Glycosylation in Cancer Cells.International journal of molecular sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

G XueDepartment of Medical Genetics, College of Basic Medical Sciences, Second Military Medical University, Shanghai, China.
H-L YanDepartment of Medical Genetics, College of Basic Medical Sciences, Second Military Medical University, Shanghai, China.
Y ZhangDepartment of Medical Genetics, College of Basic Medical Sciences, Second Military Medical University, Shanghai, China.
L-Q HaoDepartment of Colorectal Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China.
X-T ZhuDepartment of Medical Genetics, College of Basic Medical Sciences, Second Military Medical University, Shanghai, China.
Q MeiDepartment of Medical Genetics, College of Basic Medical Sciences, Second Military Medical University, Shanghai, China.
S-H SunDepartment of Medical Genetics, College of Basic Medical Sciences, Second Military Medical University, Shanghai, China.
Second Military Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous studies have established the link between aberrant microRNA (miRNA) expression and hypoxia in various neoplasms. However, how these hypoxia-related miRNAs modulate tumor progression is still unclear. Therefore, the patterns of miRNA in colorectal carcinoma cell lines in response to hypoxia or not were first screened and the hypoxia-induced repression of the miR-15-16 cluster was confirmed. Then, this repression was found to be associated with high tumor stage and poor prognosis in colorectal carcinoma and is shown to promote tumor angiogenesis and metastasis by the loss of restriction of its target gene, fibroblast growth factor-2 (FGF2). Moreover, the general and alterative promoters of the miR-15-16 host (deleted in lymphocytic leukemia 2, DLEU2) were mapped, and three c-Myc/Max binding sites in response to the hypoxia-induced repression of miR-15-16 were further identified. Finally, an enhanced stability of c-Myc/Max heterodimer promoted by increased hypoxia-inducible factor-2α (HIF-2α) was validated, and we also verified that the enhancement contributed to the hypoxia-induced repression of miR-15-16. In brief, the c-Myc-mediated transcriptional repression of miR-15-16 in hypoxia is induced by increased HIF-2α and promoted tumor angiogenesis and hematogenous metastasis by the further loss of post-transcriptional inhibition of FGF2. Our study provides a better understanding of the coping mechanisms in response to tumor hypoxia and may be helpful in developing an effective prognostic marker or treatment target against solid tumors.

Indexed as

AnimalsBasic Helix-Loop-Helix ProteinsCell HypoxiaCell Line, TumorCell MovementColorectal NeoplasmsEndothelial PAS Domain-Containing Protein 1FemaleFibroblast Growth Factor 2Gene Expression Regulation, NeoplasticHT29 CellsHumansMaleMiceMice, NudeMicroRNAsBasic Helix-Loop-Helix ProteinsEndothelial PAS Domain-Containing Protein 1Fibroblast Growth Factor 2MicroRNAsMIRN15 microRNA, humanMIRN16 microRNA, humanMYC protein, humanProto-Oncogene Proteins c-mycRNA, Small Interfering

Identifiers

PMID24704828
OpenAlexW1992329440

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.