ArticleExperimental gerontology2014
Mitochondrial ultrastructure and markers of dynamics in hepatocytes from aged, calorie restricted mice fed with different dietary fats.
Article in Experimental gerontology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- The central role of mitochondrial dysfunction in neurodegeneration: implications for therapy.Molecular and cellular biochemistry · 2026Review
- Catabolic rewiring in cancer impacts dietary interventions.Communications biology · 2025Review
- Cytochrome bAging cell · 2024Article
- Mitochondrial Dysfunction as a Signaling Target for Therapeutic Intervention in Major Neurodegenerative Disease.Neurotoxicity research · 2023Review
- The impact of diet upon mitochondrial physiology (Review).International journal of molecular medicine · 2022Review
- Article
- Mitochondrial contributions to vascular endothelial dysfunction, arterial stiffness, and cardiovascular diseases.American journal of physiology. Heart and circulatory physiology · 2021Review
- Article
- Article
- Impact of COVID-19 on Mitochondrial-Based Immunity in Aging and Age-Related Diseases.Frontiers in aging neuroscience · 2020Review
- Mitochondrial morphology regulates organellar CaFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Mitochondrial dysfunction in neurodegenerative diseases and the potential countermeasure.CNS neuroscience & therapeutics · 2019Review
- Effects of apoptosis on liver aging.World journal of clinical cases · 2019Review
- The role of mitochondria in aging.The Journal of clinical investigation · 2018Review
- Mitophagy plays a central role in mitochondrial ageing.Mammalian genome : official journal of the International Mammalian Genome Society · 2016Review
- Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice.Cell metabolism · 2016Article
- Article
- Calorie restriction as an intervention in ageing.The Journal of physiology · 2016Review
- The influence of dietary fat source on liver and skeletal muscle mitochondrial modifications and lifespan changes in calorie-restricted mice.Biogerontology · 2015Review
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
In this paper we analyzed changes in hepatocyte mitochondrial mass and ultrastructure as well as in mitochondrial markers of fission/fusion and biogenesis in mice subjected to 40% calorie restriction (CR) for 18 months versus ad libitum-fed controls. Animals subjected to CR were separated into three groups with different dietary fats: soybean oil (also in controls), fish oil and lard. Therefore, the effect of the dietary fat under CR was studied as well. Our results show that CR induced changes in hepatocyte and mitochondrial size, in the volume fraction occupied by mitochondria, and in the number of mitochondria per hepatocyte. Also, mean number of mitochondrial cristae and lengths were significantly higher in all CR groups compared with controls. Finally, CR had no remarkable effects on the expression levels of fission and fusion protein markers. However, considerable differences in many of these parameters were found when comparing the CR groups, supporting the idea that dietary fat plays a relevant role in the modulation of CR effects in aged mice.
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