ArticleBehavioural brain research2014
Partial inactivation of nucleus accumbens core decreases delay discounting in rats without affecting sensitivity to delay or magnitude.
Article in Behavioural brain research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed.
- Impulsivity in NrCAM KO Mice Is Reduced by NMDAR Antagonist MK-801 but Not by AMPAR Antagonist CNQX.NeuroSci · 2026Article
- Tyrosine Hydroxylase-Positive Nucleus Accumbens Neurons Influence Delay Discounting in a Mouse T-Maze Task.eNeuro · 2024Article
- Involvement of dopamine D3 receptor in impulsive choice decision-making in male rats.Neuropharmacology · 2024Article
- Genome-wide association study of delay discounting in Heterogeneous Stock rats.Genes, brain, and behavior · 2024Article
- Methylphenidate, but not citalopram, decreases impulsive choice in rats performing a temporal discounting task.Frontiers in psychiatry · 2024Article
- Genome-wide association study of delay discounting in Heterogenous Stock rats.bioRxiv : the preprint server for biology · 2023Article
- Selective chemogenetic inactivation of corticoaccumbal projections disrupts trait choice impulsivity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Dopamine D2 receptors in nucleus accumbens cholinergic interneurons increase impulsive choice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Dopamine D2 receptors in nucleus accumbens cholinergic interneurons increase impulsive choice.bioRxiv : the preprint server for biology · 2023Article
- A sex-dependent role for the prelimbic cortex in impulsive action both before and following early cocaine abstinence.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Which came first: Cannabis use or deficits in impulse control?Progress in neuro-psychopharmacology & biological psychiatry · 2021Review
- The use of laser capture microdissection to identify specific pathways and mechanisms involved in impulsive choice in rats.Heliyon · 2019Article
- Prelimbic Cortical Neurons Track Preferred Reward Value and Reflect Impulsive Choice during Delay Discounting Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Nucleus accumbens core lesions induce sub-optimal choice and reduce sensitivity to magnitude and delay in impulsive choice tasks.Behavioural brain research · 2018Article
- Effects of intra-accumbal administration of dopamine and ionotropic glutamate receptor drugs on delay discounting performance in rats.Behavioral neuroscience · 2017Article
- A framework for understanding and advancing intertemporal choice research using rodent models.Neurobiology of learning and memory · 2017Review
- Activational and effort-related aspects of motivation: neural mechanisms and implications for psychopathology.Brain : a journal of neurology · 2016Review
- Mechanisms of impulsive choice: III. The role of reward processes.Behavioural processes · 2016Article
- Recent Translational Findings on Impulsivity in Relation to Drug Abuse.Current addiction reports · 2014Article
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Authors and funding
2 authors.
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Abstract
Increased preference for smaller, sooner rewards (delay discounting) is associated with several behavioral disorders, including ADHD and substance use disorders. However, delay discounting is a complex cognitive process and the relationship is unclear between the pathophysiology of the disorders and the component processes underlying delay discounting, including sensitivity to reinforcer delay and sensitivity to reinforcer magnitude. To investigate these processes, male Long Evans rats were trained in one of three tasks measuring sensitivity to delay, sensitivity to magnitude, or both (typical delay discounting task). After learning the task, animals were implanted with bilateral cannulae into either the nucleus accumbens core (AcbC) or the lateral orbitofrontal cortex (lOFC), both of which have been implicated in delay discounting. Upon recovering from the surgery, a baclofen/muscimol cocktail was infused to temporarily inactivate each of these two regions and task performance was assessed. Unlike previous studies showing that lesions of the AcbC increased delay discounting, partial inactivation of the AcbC decreased delay discounting, although it had no effects on the tasks independently assessing either sensitivity to delay or magnitude. The effects of AcbC inactivation were larger in animals that had low levels of delay discounting at baseline. Inactivation of the lOFC had no effects on behavior in any task. These findings suggest that the AcbC may act to promote impulsive choice in individuals with low impulsivity. Furthermore, the data suggest that the AcbC is able to modulate delay and magnitude sensitivity together, but not either of the two in isolation.
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