ArticleAtherosclerosis2014
Gammadelta (γδ) T lymphocytes do not impact the development of early atherosclerosis.
Article in Atherosclerosis, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Fitness Training for γδ T cells in mouse and human atherosclerosis takes place in plaques and artery tertiary lymphoid organs.Genome medicine · 2026Article
- TNFSF13 Drives Atherosclerosis Progression by Targeting Macrophage Senescence.International journal of medical sciences · 2026Article
- CXCL9, IL2RB, and SPP1, potential diagnostic biomarkers in the co-morbidity pattern of atherosclerosis and non-alcoholic steatohepatitis.Scientific reports · 2024Article
- Clonally expanded memory CD8Nature aging · 2023Article
- Review
- Integrated investigation of DNA methylation, gene expression and immune cell population revealed immune cell infiltration associated with atherosclerotic plaque formation.BMC medical genomics · 2022Article
- How the immune system shapes atherosclerosis: roles of innate and adaptive immunity.Nature reviews. Immunology · 2022Review
- Phenotypic Changes of Peripheral γδ T Cell and Its Subsets in Patients With Coronary Artery Disease.Frontiers in immunology · 2022Article
- Innate and adaptive immunity: the understudied driving force of heart valve disease.Cardiovascular research · 2021Review
- Immune Mechanisms of Plaque Instability.Frontiers in cardiovascular medicine · 2021Review
- Adaptive Immune Responses in Human Atherosclerosis.International journal of molecular sciences · 2020Review
- T cell subsets and functions in atherosclerosis.Nature reviews. Cardiology · 2020Review
- Perivascular adipose tissue (PVAT) in atherosclerosis: a double-edged sword.Cardiovascular diabetology · 2018Review
- Alternative macrophages in atherosclerosis: not always protective!The Journal of clinical investigation · 2018Article
- T Cells in Atherosclerosis in Ldlr-/- and Apoe-/- Mice.Journal of immunological sciences · 2018Article
- Cytotoxic lymphocytes and atherosclerosis: significance, mechanisms and therapeutic challenges.British journal of pharmacology · 2017Review
- The role of infiltrating immune cells in dysfunctional adipose tissue.Cardiovascular research · 2017Review
- The immunology of atherosclerosis.Nature reviews. Nephrology · 2017Review
- Loss of ABCG1 influences regulatory T cell differentiation and atherosclerosis.The Journal of clinical investigation · 2016Article
- Lymphocytes in atherosclerosis.Arteriosclerosis, thrombosis, and vascular biology · 2015Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
objectiveGammadelta (γδ) T cells are a subset of pro-inflammatory innate-like T lymphocytes that serve as a bridge between innate and adaptive immunity. γδ T cells are highly enriched in cholesterol compared to αβ T cells. In this study, we aimed to identify the role of γδ T cells in atherosclerosis, a cholesterol and inflammation-driven disease.
methodsWe found that the percentages of γδ T cells are increased in ApoE(-/-) mice fed a Western diet. We generated TCRδ(-/-)ApoE(-/-) mice and fed them either rodent chow or a Western diet for ten weeks for the assessment of atherosclerosis.
resultsThe atherosclerotic lesion size in diet-fed TCRδ(-/-)ApoE(-/-) mice was similar to that of diet-fed ApoE(-/-) mice. There were no differences in cytokine production or numbers of αβ T cells in aorta of TCRδ(-/-)ApoE(-/-) mice. Plasma lipoprotein profiles were unchanged by the absence of γδ T cells.
conclusionOur data suggest that γδ T cells do not contribute to early atherosclerotic plaque development.
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Registered trials
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