ArticleNeuroscience letters2014
Enhanced scratching elicited by a pruritogen and an algogen in a mouse model of contact hypersensitivity.
Article in Neuroscience letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Therapeutic Targeting of the Bradykinin B2 Receptor in Immunological and Vascular Diseases: Insights from Kinin Biology to Clinical Outcomes.Clinical reviews in allergy & immunology · 2026Review
- Differential Diagnosis of Irritant Versus Allergic Contact Dermatitis Based on Noninvasive Methods.Dermatology practical & conceptual · 2024Article
- Itch and Pain Behaviors in Irritant Contact Dermatitis Produced by Sodium Lauryl Sulfate in Mice.International journal of molecular sciences · 2024Article
- TRPV1 in Pain and Itch.Advances in experimental medicine and biology · 2021Article
- Thermal Hyperalgesia and Mechanical Allodynia Elicited by Histamine and Non-histaminergic Itch Mediators: Respective Involvement of TRPV1 and TRPA1.Neuroscience · 2020Article
- Protease-Activated Receptor-2 Regulates Neuro-Epidermal Communication in Atopic Dermatitis.Frontiers in immunology · 2020Article
- Article
- Activation of Mast-Cell-Expressed Mas-Related G-Protein-Coupled Receptors Drives Non-histaminergic Itch.Immunity · 2019Article
- TRPA1 Channel is Involved in SLIGRL-Evoked Thermal and Mechanical Hyperalgesia in Mice.Medical sciences (Basel, Switzerland) · 2019Article
- Role of P2X3 receptors in scratching behavior in mouse models.The Journal of allergy and clinical immunology · 2019Article
- Qingpeng Ointment Ameliorates Inflammatory Responses and Dysregulation of Itch-Related Molecules for Its Antipruritic Effects in Experimental Allergic Contact Dermatitis.Frontiers in pharmacology · 2019Article
- ClJournal of neurophysiology · 2017Article
- Allergic Contact Dermatitis: A Model of Inflammatory Itch and Pain in Human and Mouse.Advances in experimental medicine and biology · 2016Article
- Central Mechanisms of Itch.Current problems in dermatology · 2016Review
- CXCR3 chemokine receptor signaling mediates itch in experimental allergic contact dermatitis.Pain · 2015Article
- Psychophysical measurements of itch and nociceptive sensations in an experimental model of allergic contact dermatitis.The journal of pain · 2015Article
- Signs of chronic itch in the mouse imiquimod model of psoriasiform dermatitis: sex differences and roles of TRPV1 and TRPA1.Itch (Philadelphia, Pa.)Article
- Article
Corrections and comments
- Commented on by
Authors and funding
5 authors.
Funding
Abstract
Chemical pruritogens and algogens evoke primarily itch and pain, respectively, when administered to the skin of healthy human subjects. However, the dominant sensory quality elicited by an algesic chemical stimulus may change in patients with chronic itch where bradykinin, elicits itch in addition to pain. Here we tested whether normally pruritic and algesic chemicals evoked abnormal itch- or pain-like behaviors in the mouse after the development of contact hypersensitivity (CHS), an animal model of allergic contact dermatitis. Mice previously sensitized to a hapten (squaric acid dibutylester) applied to the abdomen, exhibited spontaneous itch-like scratching and pain-like wiping directed to the site on the cheek of the CHS elicited by a subsequent challenge with the same hapten. In comparison with responses of control mice, CHS mice exhibited a significant increase in the scratching evoked by bovine adrenal medulla 8-22, a peptide that elicits a histamine-independent itch, but did not alter the scratching to histamine. Bradykinin, an algogen that elicited only wiping in control mice, additionally evoked significant scratching in CHS mice. Thus, within an area of CHS, histamine-independent itch is enhanced and chemically evoked pain is accompanied by itch.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.